This content is machine translated Sleep disorder Sleep medicine in transition: new goals and a reassessment of old hypnotics Sleep and circadian rhythm disorders (SCRDs) often occur as early comorbidities in neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD), often decades before typical symptoms appear. Sleep...…
View Post 4 min This content is machine translated Epilepsy Cannabidiol for refractory epilepsy syndromes The pharmaceutical formulation of high-purity cannabidiol is approved for the treatment of seizures associated with Lennox-Gastaut syndrome, Dravet syndrome and tuberous sclerosis complex. Despite many years of clinical experience, there...…
View Post 4 min This content is machine translated Pulmonary sarcoidosis Prednisone vs. MTX: a draw after 24 weeks Pulmonary sarcoidosis remains a persistent clinical challenge in respiratory medicine. Although glucocorticoids have long been the mainstay of first-line therapy, their side effects often complicate long-term treatment. In recent years,...…
View Post 4 min This content is machine translated Multiple sclerosis Vitamin D as an adjuvant in multiple sclerosis: statistical success and clinical limitations Various risk factors are involved in the pathogenesis of multiple sclerosis, with vitamin D deficiency being associated with an increased risk of MS since the 1970s. Disease-modifying therapies aim to...…
View Post 6 min This content is machine translated Chronic insomnia in adults: Guideline recommendations CBT-i as first choice – pharmacotherapy as secondary intervention Sleep disorders are often associated with pronounced daytime sleepiness, difficulty concentrating and increased feelings of stress. Diagnosis is generally based on the clinical history; if necessary, an actigraphy or polysomnigraphy...…
View Post 4 min RX Education Geriatrics Neurology Pharmacology and toxicology Studies Opicapon: double benefit for motor function and sleep in Parkinson’s disease Sleep disorders are among the most common non-motor Parkinson’s symptoms. The targeted treatment of sleep disorders is an important part of Parkinson’s therapy and can significantly improve quality of life....…
View Post 5 min This content is machine translated Multiple sclerosis Avoiding the nocebo trap with natalizumab biosimilars Monoclonal antibodies such as natalizumab are indispensable for multiple sclerosis therapy. A first recently approved biosimilar is clinically equivalent, as studies have shown. Nevertheless, reservations are widespread in practice. Patients...…
View Post 9 min This content is machine translated Psoriasis: intervening in the inflammatory cascade Advantages of early biologic therapy and oral peptide as a beacon of hope The question of whether early biologics treatment can have a lasting effect on the course of psoriasis is the focus of numerous research projects. The GUIDE study investigated the corresponding...…
View Post 4 min This content is machine translated Bipolar disorder, anxiety disorder, depression Lurasidone as monotherapy for bipolar I depression with anxiety symptoms Comorbid anxiety is common in patients with bipolar disorder. This comorbidity is associated with increased disease severity and poorer treatment response. A study with lurasidone 20-60 mg/day showed significant efficacy...…
View Post 4 min This content is machine translated GLP1-RA therapy Improvement in either weight or HbA1c – but never both Numerous studies show that glucagon-like peptide-1 receptor agonists (GLP1-RA) can significantly reduce the risk of diabetes-related complications and also reduce mortality. Despite their proven efficacy in trial designs, patient response...…
View Post 6 min This content is machine translated Suicide Dealing with trauma after suicide loss: What do bereaved people experience as effective? Every year, over 100 million people around the world are affected by suicide. Survivors often experience long-lasting, severe trauma and have an increased risk of mental illness and suicidal thoughts...…
