This content is machine translated Non-small cell lung cancer The first targeted therapy for KRAS G12C mutation [1]. After decades of effort, it is now possible for the first time to provide patients with KRAS G12C-mutated non-small cell lung cancer with an effective targeted therapy [1,2]. In the…
View Post 3 min This content is machine translated Study report: Online survey Molecular diagnostics in dermatology In the age of personalized medicine, molecular diagnostics is also becoming increasingly important in dermatology. In a cross-sectional study published in the JDDG, their use in the areas of oncological,…
View Post 9 min This content is machine translated Hepatocellular carcinoma Systemic treatment of HCC – combination therapies on the rise Hepatocellular carcinoma (HCC) is the most common primary liver cell tumor and presents a challenge in systemic treatment with its intrinsic resistance to classical chemotherapeutic agents. The responsible clinician must… CME-Test
View Post 5 min This content is machine translated Modern lipid management Treating dyslipidemia in diabetes in a target-oriented manner Diabetes is associated with increased cardiovascular morbidity and mortality. Risk-stratified LDL cholesterol lowering is an important component of diabetes therapy and may improve clinical prognosis. In order to achieve the…
View Post 2 min This content is machine translated Chronic nodular prurigo Pruriginous lesional skin exhibits specific DNA methylation signature The question of which mechanisms contribute to the chronification of pruritus in chronic nodular prurigo is the subject of current research. It is hoped that new insights will be gained…
View Post 2 min This content is machine translated Blood-based analytics: clinical application “Liquid biopsy” in malignant melanoma As a biomarker for monitoring the progression of tumor diseases, the detection of tumor cell DNA in blood using next-generation sequencing (“liquid biopsy”) is becoming increasingly important. This also applies…
View Post 5 min This content is machine translated Diabetes Technology Hybrid closed-loop systems: more than glycemic control The combination of continuous glucose monitoring (CGM) with a sensor-controlled insulin pump has already brought us a lot closer to the vision of an “artificial pancreas”. Compared to insulin pump…
View Post 3 min This content is machine translated Casein Milk may increase MS symptoms People with multiple sclerosis often complain of more severe disease symptoms after consuming dairy products. A protein in cow’s milk can trigger inflammation that targets the “insulating layer” around nerve…
View Post 3 min This content is machine translated Comorbidity Research Psychosocial impact of rosacea Rosacea can have a significant impact on the psychological well-being of sufferers. “Awareness” of the psychological dimension of this dermatosis and of the multiple treatment options is important to improve…
View Post 2 min This content is machine translated Moderate to severe atopic dermatitis “Flares” affect the quality of life Current empirical data underscore the high “burden of disease” in patients with inadequately controlled atopic dermatitis and indicate that there remains a need for highly effective and subgroup-specific systemic therapies.
View Post 4 min This content is machine translated Immuno-oncology Immune checkpoint inhibitors in carcinoma patients – update for the primary care physician. Therapy with anti-PD-1, anti-PDL-1 and anti-CTLA-4 antibodies can also achieve long-term remissions in patients with previously incurable tumor diseases. Whether a carcinoma patient will respond to treatment with checkpoint inhibitors…
