Genetic predisposition, sarcopenia screening and pre-therapeutic assessment

Lower urinary tract symptoms (LUTS ) are common in middle-aged and older men and affect both the storage and flow of urine. In addition to established risk factors such as prostate enlargement and chronic inflammation, genetic influences and general physical condition – in particular sarcopenia – are now also coming into focus as decisive parameters when it comes to predicting the response to treatment. At the same time, current guidelines call for a structured, pre-therapeutic assessment in order to avoid diagnostic errors and unnecessary invasive procedures and instead tailor therapies to the individual patient.