Rare malignancy from a dermatological perspective

Blastic plasmacytoid dendritic cell neoplasia (BPDCN) is an aggressive hematologic malignancy originating from immature plasmacytoid dendritic cell (PDC) precursors. The initial manifestation of BPDCN often consists of cutaneous lesions. In this educational article, the clinical, histologic and therapeutic aspects of BPDCN are discussed from a dermatologic perspective.