Medizinonline Medizinonline
  • News
    • News
    • Market & Medicine
  • Patients
    • Disease patterns
    • Diagnostics
    • Therapy
  • Partner Content
    • Dermatology
      • Atopic dermatitis and psoriasis news
      • Dermatology News
    • Diabetes
      • Dia-Month Club – Type 2 Diabetes
      • Diabetes in Motion
      • Diabetes Podcasts
    • Gastroenterology
      • IBD matters
      • Forum Gastroenterology
      • Ozanimod: ulcerative colitis
      • Reflux Update
    • Immunology
      • Primary immunodeficiency – exchange of experience
    • Vaccinate
      • Herpes zoster
    • Infektiologie
    • Neurology
      • EXPERT ULTRASONIC: Introduction to ultrasound-guided injection
      • MS News
      • MS Therapy in Transition
    • Oncology
      • Swiss Oncology in motion
    • Orthopedics
      • Osteoporosis in motion
    • Phytotherapie
    • Practice Management
      • Aargau Cantonal Bank
      • Claraspital
    • Psychiatry
      • Geriatric Psychiatry
    • Rheumatology
  • Departments
    • Allergology and clinical immunology
    • General Internal Medicine
    • Anesthesiology
    • Angiology
    • Surgery
    • Dermatology and venereology
    • Endocrinology and Diabetology
    • Nutrition
    • Gastroenterology and Hepatology
    • Genetics
    • Geriatrics
    • Gynecology
    • Hematology
    • Infectiology
    • Cardiology
    • Nephrology
    • Neurology
    • Emergency and intensive care medicine
    • Nuclear Medicine
    • Oncology
    • Ophthalmology
    • ORL
    • Orthopedics
    • Pediatrics
    • Pharmacology and toxicology
    • Pharmaceutical medicine
    • Phlebology
    • Physical medicine and rehabilitation
    • Pneumology
    • Prevention and health care
    • Psychiatry and psychotherapy
    • Radiology
    • Forensic Medicine
    • Rheumatology
    • Sports Medicine
    • Traumatology and trauma surgery
    • Tropical and travel medicine
    • Urology
    • Dentistry
  • CME & Congresses
    • CME continuing education
    • Congress Reports
    • Congress calendar
  • Practice
    • Noctimed
    • Practice Management
    • Jobs
    • Interviews
  • Log In
  • Register
  • My account
  • Contact
  • English
    • Deutsch
    • Français
    • Italiano
    • Português
    • Español
  • Publications
  • Contact
  • Deutsch
  • English
  • Français
  • Italiano
  • Português
  • Español
Subscribe
Medizinonline Medizinonline
Medizinonline Medizinonline
  • News
    • News
    • Market & Medicine
  • Patienten
    • Krankheitsbilder
    • Diagnostik
    • Therapie
  • Partner Content
    • Dermatology
      • Atopic dermatitis and psoriasis news
      • Dermatology News
    • Diabetes
      • Dia-Month Club – Type 2 Diabetes
      • Diabetes in Motion
      • Diabetes Podcasts
    • Gastroenterology
      • IBD matters
      • Forum Gastroenterology
      • Ozanimod: ulcerative colitis
      • Reflux Update
    • Immunology
      • Primary immunodeficiency – exchange of experience
    • Vaccinate
      • Herpes zoster
    • Infektiologie
    • Neurology
      • EXPERT ULTRASONIC: Introduction to ultrasound-guided injection
      • MS News
      • MS Therapy in Transition
    • Oncology
      • Swiss Oncology in motion
    • Orthopedics
      • Osteoporosis in motion
    • Phytotherapie
    • Practice Management
      • Aargau Cantonal Bank
      • Claraspital
    • Psychiatry
      • Geriatric Psychiatry
    • Rheumatology
  • Departments
    • Fachbereiche 1-13
      • Allergology and clinical immunology
      • General Internal Medicine
      • Anesthesiology
      • Angiology
      • Surgery
      • Dermatology and venereology
      • Endocrinology and Diabetology
      • Nutrition
      • Gastroenterology and Hepatology
      • Genetics
      • Geriatrics
      • Gynecology
      • Hematology
    • Fachbereiche 14-26
      • Infectiology
      • Cardiology
      • Nephrology
      • Neurology
      • Emergency and intensive care medicine
      • Nuclear Medicine
      • Oncology
      • Ophthalmology
      • ORL
      • Orthopedics
      • Pediatrics
      • Pharmacology and toxicology
      • Pharmaceutical medicine
    • Fachbereiche 26-38
      • Phlebology
      • Physical medicine and rehabilitation
      • Phytotherapy
      • Pneumology
      • Prevention and health care
      • Psychiatry and psychotherapy
      • Radiology
      • Forensic Medicine
      • Rheumatology
      • Sports Medicine
      • Traumatology and trauma surgery
      • Tropical and travel medicine
      • Urology
      • Dentistry
  • CME & Congresses
    • CME continuing education
    • Congress Reports
    • Congress calendar
  • Practice
    • Noctimed
    • Practice Management
    • Jobs
    • Interviews
Login

Sie haben noch keinen Account? Registrieren

  • Twelve-year-old girl with skin abnormality on thigh

Skin colored subcutaneous papules – what is it?

    • Cases
    • Dermatology and venereology
    • Pediatrics
    • RX
  • 2 minute read

Case report: A twelve-year-old girl presented with a skin-colored change on the medial right thigh that had been present since early childhood. This was basically asymptomatic, but seemed to have been expanding for several years and was bothering the patient, so a presentation was made to discuss therapeutic options.

Dermatologic examination revealed an approximately 15 cm plaque on the medial right thigh consisting of multiple, confluent, partially anetodermic, skin-colored, subcutaneous papules and nodules (Fig. 1).

Quiz

Based on this information, what is the most likely diagnosis?

A Connective tissue nevus
B Fibroepithelioma (Pinkus tumor)
C Lymphangioma
D nevus lipomatosus superficialis
E Dermatofibrosarcoma protuberans

Diagnosis and Discussion: This skin lesion is a nevus lipomatosus superficialis (NLS). This is a rare hamartoma characterized by grouped, painless, skin-colored to yellowish papules and nodules and has a smooth to cerebriform surface. It was first described in 1921. Two forms are distinguished. One is the classic Hoffmann-Zurhelle type, which typically presents in children and adolescents with multiple papules and nodules in a linear or segmental distribution pattern on the distal trunk and thighs. This is distinguished from the solitary standing form, which can occur mainly in adults and on any part of the body. There is usually no positive family history.

The cause is still unclear. There is a theory of misdirected deposition of fat cells during the embryonic phase, conversion of pericytes into fat cells, or degeneration of connective tissue. A 2p24 deletion in NLS has been described, but the significance of this genetic alteration is unclear.

Fine tissue examination typically reveals numerous collections of mature fat cells located in the dermis between collagenous fibers, as well as reduced but otherwise usually normal adnexal structures. Cases with associated malformations and tumors of the hair follicles and sebaceous glands have also been described.

Children and adolescents may experience mild to moderate growth over a few years before stagnation sets in. There is no tendency to malignant degeneration.

The treatment of choice is usually excision of the affected areas (if possible with a good aesthetic result). Alternatively, treatment with theCO2 laser is also described. Due to the extent of the finding and the nevertheless rather inconspicuous location of the nevus, the family initially decided against surgical intervention.

 

Further reading:

  • Hoffmann E, Zurhelle E: On a nevus lipomatosus cutaneous superficialis of the left gluteal region. Arch Clin Exp Dermatol 1921; 130: 327-333.
  • Cardot-Leccia N, et al: Nevus lipomatosus superficialis: a case report with a 2p24 deletion. Br J Dermatol 2007 Feb; 156(2): 380-381.
  • Kim RH, et al: Nevus lipomatosus superficialis. Dermatol Online J 2014 Dec 16; 20(12).
Autoren
  • Dr. med. Agnes Schwieger-Briel
  • Alexandra Smith
  • Dr. med. Aline Büchner
  • Dr. med. Martin Theiler
  • PD Dr. med. Lisa Weibel
Publikation
  • DERMATOLOGIE PRAXIS
Related Topics
  • CO2
  • nevus lipomatosus
  • NLS
  • Papules
  • plaque
  • Quincke
Previous Article
  • 1st Swiss Heart Day

The 24/7 society makes us tired and fat

  • Cardiology
  • Congress Reports
  • Nutrition
  • RX
  • Studies
View Post
Next Article
  • Advanced training course in aesthetic dermatology

Who is eligible for peeling and how to avoid complications?

  • Dermatology and venereology
  • Education
  • RX
View Post
You May Also Like
View Post
  • 6 min
  • Case Report

Breast cancer metastases in the bladder

    • Cases
    • Education
    • Gynecology
    • Oncology
    • RX
    • Urology
View Post
  • 11 min
  • Findings from the ALS Symposium 2024 in Montreal

Current and future approaches in the treatment of amyotrophic lateral sclerosis (ALS)

    • Congress Reports
    • Interviews
    • Neurology
    • RX
    • Studies
View Post
  • 8 min
  • Efficacy, mechanism of action and clinical effects

Garlic and high blood pressure

    • Cardiology
    • Education
    • General Internal Medicine
    • Pharmaceutical medicine
    • Phytotherapy
    • RX
    • Studies
View Post
  • 7 min
  • Moderate to severe chronic hand eczema

Delgocitinib cream – first topical pan-JAK inhibitor approved in Switzerland

    • Allergology and clinical immunology
    • Dermatology and venereology
    • Education
    • Infectiology
    • Market & Medicine
    • Pharmacology and toxicology
    • RX
View Post
  • 9 min
  • Wild-type transthyretin amyloid cardiomyopathy (ATTRwt-CA)

Diagnosis at an early stage, prognostic classifications and outlook

    • Cardiology
    • Education
    • RX
    • Studies
View Post
  • 4 min
  • Case report: Drug-induced hepatitis

Rare side effect of tirzepatide therapy

    • Cases
    • Education
    • Endocrinology and Diabetology
    • Gastroenterology and Hepatology
    • Pharmacology and toxicology
    • RX
    • Studies
View Post
  • 4 min
  • Plea for sex-specific neurology

Migraine in men: underdiagnosed, underestimated, under-researched

    • Education
    • Neurology
    • RX
    • Studies
View Post
  • 4 min
  • Prurigo nodularis

Retrospective analyses of large data sets from everyday practice

    • Allergology and clinical immunology
    • Congress Reports
    • Dermatology and venereology
    • RX
Top Partner Content
  • Forum Gastroenterology

    Zum Thema
  • Herpes zoster

    Zum Thema
  • Dermatology News

    Zum Thema
Top CME content
  • 1
    Patience, knowledge and persistence in therapy
  • 2
    Sarcopenia and malnutrition in the context of pneumological rehabilitation
  • 3
    Medical and psychosocial perspectives
  • 4
    New nomenclature for non-alcoholic fatty liver disease
  • 5
    Examinations and considerations before therapy

Newsletter

Sign up and stay up to date

Subscribe
Medizinonline
  • Contact
  • General terms and conditions
  • Imprint

Input your search keywords and press Enter.