This content is machine translated Moderate to severe atopic dermatitis Established and novel biologics – the therapeutic landscape is in flux Clinically, atopic dermatitis (AD) manifests itself through a polymorphic picture of efflorescences, with pruritus and xerosis in the foreground. In addition to the antibody therapies dupilumab, tralokinumab and lebrikizumab, which...…
View Post 4 min This content is machine translated From symptom to diagnosis Abdominal pain – Inguinal testicles Undescended testicles (maldescensus testis) are one of the most common congenital anomalies of the urogenital tract in male newborns. Testicular dystopia describes a positional anomalyof the testicle on its natural...…
View Post 4 min This content is machine translated Case series Mast cell activation syndrome (MCAS) MCAS is now understood as an independent disorder in contrast to systemic or cutaneous mastocytosis. The signs and symptoms can affect the skin, the gastrointestinal tract and the cardiovascular system,...…
View Post 5 min This content is machine translated Gestational diabetes Significant CVD prevention through five lifestyle factors Cardiovascular disease (CVD) is a major cause of morbidity and mortality in women worldwide, particularly those with adverse pregnancy outcomes such as gestational diabetes (GD). Although GD is an established...…
View Post 5 min This content is machine translated Nutritional supplements and cognition 5-HTP: The serotonin booster for cognition in old age Can a dietary supplement measurably improve cognitive ageing processes? When 5-HTP is useful – and when caution is needed due to interactions. A randomized study shows: 5-HTP increases serotonin levels,...…
View Post 5 min This content is machine translated Friedreich's ataxia Interim analyses of the PROFA study show “Unmet needs” The PROFA study focuses, among other things, on patient-reported psychosocial effects of Friedreich’s ataxia (FRDA) at different stages of the disease. The study comprises a cohort of FRDA patients in...…
View Post 5 min This content is machine translated Diabetic retinopathy Addressing ER stress with GLP1-RA Diabetic retinopathy (DR) is one of the leading causes of vision loss in diabetes. Current therapies, including anti-VEGF agents and laser photocoagulation, target late-stage vascular changes but offer limited benefit...…
View Post 4 min This content is machine translated Study report Sphingolipid profile in early-stage primary biliary cholangitis Using ultra-high performance liquid chromatography coupled with tandem mass spectrometry (UHPLC-MS/MS), a Polish research team discovered interesting new insights into the changes in sphingolipid metabolism in patients with early-stage primary...…
View Post 6 min This content is machine translated Angiosarcoma of the heart A diagnostic and therapeutic “black box” Primary angiosarcomas of the heart are among the rarest and most aggressive malignant tumors. The unspecific symptoms, rapid progression and complex differential diagnosis make early detection considerably more difficult. Despite...…
View Post 5 min This content is machine translated Ataxias Friedreich’s ataxia: when the energy metabolism attacks the nervous system Energy deficiency instead of pure oxidative stress: New data show that in Friedreich’s ataxia, disturbances in fatty acid and ketone body metabolism in particular contribute to selective neurodegeneration. The article...…
View Post 3 min This content is machine translated Risk of osteoporosis in autoimmune liver diseases Always determine bone density in PBC, PSC and AIH Studies show that primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC) and autoimmune hepatitis (AIH) are associated with a significantly increased risk of developing osteopenia or osteoporosis. For this reason,...…
