This content is machine translated Liquid Biopsy The future of oncological diagnostics With the increasing variety of personalized and immuno-oncological therapeutic options, the importance of predictive markers is also increasing. To date, tissue diagnostics, including invasive biopsy, are necessary to determine this.…
View Post 5 min This content is machine translated News from the lung cancer pipeline First targeted substance in KRAS mutation and bispecific immunotherapy While targeted therapies in non-small cell lung cancer (NSCLC) have been on the rise for years, such an option for KRAS-mutatedtumors has been lacking. The small molecule inhibitor Sotorasib, which…
View Post 7 min This content is machine translated Non-infectious complications after HSCT Cure for multiple sclerosis at any price? Hematopoietic stem cell transplantation (HSCT) is used as ultima ratio in multiple sclerosis. The reboot of the immune system is aimed at healing, but carries strong side effects. Both infectious…
View Post 5 min This content is machine translated Relapsed/refractory multiple myeloma The BCMA molecule as a beacon of hope The prognosis in relapsed and refractory multiple myeloma (RRMM) remains grim. Now, at the annual meeting of the American Society of Hematology (ASH), data have been presented that raise faint…
View Post 4 min This content is machine translated Chronic inflammatory bowel disease (CED) Two new biomarkers identified for targeted therapy Surrogate markers have an important role in the disease management of IBD. Researchers found evidence that microbial butyrate synthesis may predict therapeutic efficacy and thus play an important role in…
View Post 4 min This content is machine translated Acute generalized exanthematous pustulosis (AGEP). Not just a T cell-mediated disease? Immunopathological studies have shown that not only T cells play a role in drug reactions, especially in AGEP, but also IL36 cytokines and other mediators are involved. These findings are…
View Post 4 min This content is machine translated Psoriatic arthritis (PsoA) HLA alleles as genetic biomarkers for PsoA – an update. Psoriatic arthritis (PsoA) is a common comorbidity of psoriasis. Despite the high prevalence, arthritic symptoms often remain undiagnosed. In addition to the CASPAR classification (“Classification Criteria for Psoriatic Arthritis”), there…
View Post 5 min This content is machine translated Moderate and severe plaque psoriasis From Immunopathogenesis to Highly Effective Therapies – Enduring Lesion Freedom as the Goal Translational approaches have revolutionized the treatment options for psoriasis. New findings in the field of epidermal immunopathology form the basis for the optimization of highly effective substances. The new generation…
View Post 2 min This content is machine translated Pancreatic Cancer Effectiveness of treatment depends on molecular prerequisites Pancreatic cancer is one of the greatest challenges in oncologic therapy. Mortality is extremely high despite intensive research. New treatment options are urgently needed. A team of researchers has now…
View Post 6 min This content is machine translated Diabetes phenotyping Biomarker-associated clustering verified by multiple studies Phenotyping and subclassification of diabetic patients is becoming increasingly important to provide patient-adapted treatment options. Meanwhile, there are several cluster analyses that could reveal certain specific patterns of patient characteristics.…
View Post 3 min This content is machine translated Non-small cell lung cancer and other solid tumors In the pipeline: KRAS G12C inhibitor Sotorasib The KRAS gene is one of the most frequently mutated oncogenes in human cancers and thus represents a promising target in the therapy of diverse solid tumors. Sotorasib is currently…
