This content is machine translated Sentinel function of the P-glycoprotein The ABCB1 test for optimizing therapy with antidepressants Overcoming the blood-brain barrier is an important prerequisite for the efficacy of antidepressants. The essential component of the blood-brain barrier is the P-glycoprotein, which is encoded by the ABCB1 gene…
View Post 2 min This content is machine translated Liquid biopsy Blood instead of tissue For tumors where classical tissue biopsy (e.g. fine needle aspiration) is difficult or involves considerable risk, liquid biopsy, i.e. the analysis of mutated genetic material via blood, offers a promising…
View Post 3 min This content is machine translated Guest article by the Foundation for People with Rare Diseases The increasing importance of genetics in medicine In medicine, one must think of the possibility of a genetic effect. Familiarity may be indicative, but genetic diseases also occur sporadically. With state-of-the-art high-throughput sequencing, diagnoses can now be…
View Post 3 min This content is machine translated Guest article by the Foundation for People with Rare Diseases Ways of diagnostics – genetic testing for medical purposes The enormous progress made in recent years in the field of human genetics has already led to the identification of the cause of more than four thousand genetic (congenital) diseases.…
View Post 9 min This content is machine translated Medicine and genetics Genetic counseling – when and for whom? Genetic counseling is voluntary, open-ended, non-directive, and comprehensive. The question is defined by the person seeking advice in his or her personal context. Anamnestic diagnoses must be questioned and checked…
View Post 3 min This content is machine translated Newly diagnosed multiple myeloma Does a proteasome inhibitor offer new therapeutic options? One study discussed at the ASH meeting involved a regimen consisting of oral MLN9708 administered twice weekly plus lenalidomide and dexamethasone in patients with newly diagnosed multiple myeloma. It concludes…
View Post 6 min This content is machine translated Interview at ASCO GI on new data from the OPUS study. “We are a good step closer to personalized therapy in mCRC” In the treatment of metastatic colorectal cancer, there were new results on subgroup analyses of the OPUS trial at this year’s ASCO GI in San Francisco. As previously shown in…
View Post 4 min This content is machine translated Metastatic colorectal carcinoma To what extent does aspirin affect survival? More recently, studies have shown that aspirin improves overall survival in subgroups with colorectal cancer, specifically those with PIK3CA mutations. To test whether regular aspirin use is associated with survival…
View Post 6 min This content is machine translated Nodal lymphoma from the pathology point of view Update for daily practice A persistent lymphadenopathy is a clear indication for further histopathological diagnosis. A detailed medical history as well as knowledge of previous diseases, manipulations and drug therapies are essential for a…
View Post 4 min This content is machine translated HER2-positive breast cancer and lymphoma New applications and antibodies The antibody-drug conjugate trastuzumab emtansine, T-DM1 (Kadcyla®), is composed of the antibody trastuzumab and the chemotherapeutic agent DM1 and is currently being investigated for the treatment of HER2-positive cancers. It…
View Post 4 min This content is machine translated Multiple Myeloma and MDS Something has happened in therapy The diagnosis and treatment of multiple myeloma (MM) and myelodysplastic syndromes (MDS) have undergone great development in recent years. Modern diagnostic procedures became qualitatively better and more widely available, new…
