This content is machine translated Advanced stage malignant melanoma Targeted therapy with BRAF/MEK inhibitors – an update. Patients with non-resectable metastatic melanoma with BRAFV600 mutation should first be evaluated for eligibility for immunotherapy. In addition to checkpoint inhibition, however, targeted therapy with BRAF-MEK inhibitors is now an…
View Post 4 min This content is machine translated Psoriasis Tissue-resident memory T cells as “key players”. Immunological memory plays an important role in the pathogenesis of psoriasis. Increasingly, researchers are focusing on tissue resident memory T-cells (TRM cells). This is because the persistence of TRM cells…
View Post 3 min This content is machine translated Type 1 diabetes The autoimmune polyglandular syndrome in the focus of attention Genetic predisposition plays a crucial role as a risk factor in type 1 diabetes and associated autoimmune disorders. In addition, antibody determination plays a key role in the diagnosis and…
View Post 3 min This content is machine translated Test procedure Breast cancer early detection using biomarkers – where do we stand? Early detection of breast cancer still offers the best chance of cure. Mammography is the benchmark for screening, but is subject to technical, logistical, and diagnostic limitations. For this reason,…
View Post 3 min This content is machine translated Study report: Online survey Molecular diagnostics in dermatology In the age of personalized medicine, molecular diagnostics is also becoming increasingly important in dermatology. In a cross-sectional study published in the JDDG, their use in the areas of oncological,…
View Post 2 min This content is machine translated Chronic nodular prurigo Pruriginous lesional skin exhibits specific DNA methylation signature The question of which mechanisms contribute to the chronification of pruritus in chronic nodular prurigo is the subject of current research. It is hoped that new insights will be gained…
View Post 2 min This content is machine translated Blood-based analytics: clinical application “Liquid biopsy” in malignant melanoma As a biomarker for monitoring the progression of tumor diseases, the detection of tumor cell DNA in blood using next-generation sequencing (“liquid biopsy”) is becoming increasingly important. This also applies…
View Post 6 min This content is machine translated Von Willebrand syndrome What is the importance of genetic testing? As the most common hereditary clotting disorder, Von Willebrand syndrome affects about one in a thousand people. With new diagnostic possibilities and findings in the field of molecular genetics, the question…
View Post 4 min This content is machine translated Pheochromocytomas and paragangliomas Rare neuroendocrine tumors – individualized patient management is essential If a catecholamine-secreting tumor is suspected, determination of metanephrines in free plasma is a sensitive diagnostic method. Paroxysmal hypertension is a common symptom. Depending on the laboratory findings, an imaging…
View Post 4 min This content is machine translated Non-small cell lung cancer Molecular diagnostics under the microscope To date, molecular testing in non-small cell lung cancer (NSCLC) has been reserved primarily for stage IV patients. However, with the introduction of targeted therapies also in earlier tumor stages,…
View Post 3 min This content is machine translated Biomarker-based stratification Prediction of the therapy response of atopic patients In the context of new targeted therapies and the goal of precision medicine, stratification of patients based on their endotype is becoming increasingly important. Using the method of “deep phenotyping,”…
