This content is machine translated Type 2 diabetes Multifactorial goal-directed therapy for under-50s. Type 2 diabetes often develops insidiously and over a long period of time. In those under 50, metabolic syndrome is often associated. Special attention should be paid to cardiovascular risk…
View Post 4 min This content is machine translated Atopic dermatitis Empirical data with dupilumab confirm the empirical evidence The biologic Dupilumab has proven itself under “real-life” conditions and has already received an extension of approval in the EU for the age group 12 years and older. At the…
View Post 7 min This content is machine translated Chronic renal failure Nephroprotection – progress at last! Nephroprotection includes interventions that slow GFR decline over time, thereby delaying end-stage renal failure. The most recent intervention is the use of SGLT2 inhibitors in patients with diabetic nephropathy.
View Post 2 min This content is machine translated Microbiome Does depression go through the stomach? More than just a “gut feeling”: antibiotic reduces depression behavior via changes in the composition of the intestinal flora and thereby inhibits an “inflammatory process” in the brain.
View Post 1 min This content is machine translated Squamous cell carcinoma Pembrolizumab as first-line therapy reduces mortality rate In a phase III trial, pembrolizumab improved overall survival in patients with recurrent or metastatic head and neck squamous cell carcinoma.
View Post 2 min This content is machine translated Eosinophilic asthma Mepolizumab now also available as pen and prefilled syringe At the beginning of August 2019, GSK received approval from the EMA for two new dosage forms of mepolizumab: The IL-5 antibody can now also be administered as a pen…
View Post 6 min This content is machine translated Hawthorn extract What are the pharmacological bases of the cardioprotective effects? The empirically proven positive effects of hawthorn extract range from vasodilation and endothelial modulation to influencing cholesterol metabolism and other cardiovascular-relevant parameters. This article highlights the underlying biochemical mechanisms of…
View Post 3 min This content is machine translated Colorectal Cancer Focus on combination therapies Triple for colorectal cancer – for the first time, studies have shown clear superiority of a triple combination of encorafenib, binimetinib and cetuximab in progressive metastatic colorectal tumors.
View Post 7 min This content is machine translated Aortic valve replacement The most frequent arrhythmias after AKE or TAVI Narrowing of the aortic valve is the most common acquired valve defect and is corrected by AKE or TAVI. However, despite advances in therapy, rhythm problems often occur. What to…
View Post 3 min This content is machine translated Chronic inflammatory skin diseases Positive long-term effects in moderate to severe psoriasis Recently published data from the multicenter LIBERATE study confirm the favorable benefit-risk profile of apremilast with long-term use. This is a significant advance for the treatment options of this patient…
View Post 1 min This content is machine translated Migraine prevention Peptide receptor blockade also effective and safe in the long term It is estimated that about 11% of the population suffers from migraine. Effective therapeutic options, especially for prophylaxis, are therefore urgently needed. Study results now also confirm long-term efficacy for…
