Clonal or reactive causes?

The range of causes of blood count changes is diverse. A bone marrow puncture should be performed at a low threshold if red flags are present and is carried out, for example, to confirm the diagnosis of B-lymphoblastic leukemia (B-ALL). Prompt, efficient clarification is also essential in cases of thrombocytopenia. Thrombotic thrombocytopenic purpura (TTP) is a life-threatening thrombotic microangiopathy caused by a deficiency of the enzyme ADAMTS13.