Cutaneous symptoms, along with articular involvement, are among the most common organ involvement of systemic lupus erythematosus (SLE). In addition to positive ANA findings, further antibodies are indicative for laboratory diagnosis. If patients are suspected of having CLE, the CLASI can be used – a validated short test procedure to assess disease activity. Histological detection is obligatory to confirm the suspected clinical diagnosis; direct immunofluorescence or photoprovocation tests are used less frequently.