Current evidence suggests that the benefits of low-dose steroid therapy are greater than the harms in elderly patients with rheumatoid arthritis (RA). This is evident from the GLORIA study, in which prednisolone 5 mg/d in combination with DMARDs produced beneficial results in a placebo comparison. The use of JAK-i in elderly RA patients was evaluated in the ORAL-SURVEILLANCE study. Due to potential risks, the EMA urges caution in this patient population.
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