From skin barrier disorder to atopic march?

An early onset and persistent course of atopic dermatitis are the strongest predictors of atopic march. New diagnostic methods such as electrical impedance spectroscopy and the analysis of biomarkers from tape strips offer the potential to detect barrier dysfunction early and non-invasively, even before clinical symptoms appear. Therapeutic approaches that not only control inflammation but also actively restore the barrier function could have a lasting positive impact on the course of allergic diseases, as recent studies have shown.