Medizinonline Medizinonline
  • News
    • News
    • Market & Medicine
  • Patients
    • Disease patterns
    • Diagnostics
    • Therapy
  • Partner Content
    • Dermatology
      • Atopic dermatitis and psoriasis news
      • Dermatology News
    • Diabetes
      • Dia-Month Club – Type 2 Diabetes
      • Diabetes in Motion
      • Diabetes Podcasts
    • Gastroenterology
      • IBD matters
      • Forum Gastroenterology
      • Ozanimod: ulcerative colitis
      • Reflux Update
    • Immunology
      • Primary immunodeficiency – exchange of experience
    • Vaccinate
      • Herpes zoster
    • Infektiologie
    • Neurology
      • EXPERT ULTRASONIC: Introduction to ultrasound-guided injection
      • MS News
      • MS Therapy in Transition
    • Oncology
      • Swiss Oncology in motion
    • Orthopedics
      • Osteoporosis in motion
    • Phytotherapie
    • Practice Management
      • Aargau Cantonal Bank
      • Claraspital
    • Psychiatry
      • Geriatric Psychiatry
    • Rheumatology
  • Departments
    • Allergology and clinical immunology
    • General Internal Medicine
    • Anesthesiology
    • Angiology
    • Surgery
    • Dermatology and venereology
    • Endocrinology and Diabetology
    • Nutrition
    • Gastroenterology and Hepatology
    • Genetics
    • Geriatrics
    • Gynecology
    • Hematology
    • Infectiology
    • Cardiology
    • Nephrology
    • Neurology
    • Emergency and intensive care medicine
    • Nuclear Medicine
    • Oncology
    • Ophthalmology
    • ORL
    • Orthopedics
    • Pediatrics
    • Pharmacology and toxicology
    • Pharmaceutical medicine
    • Phlebology
    • Physical medicine and rehabilitation
    • Pneumology
    • Prevention and health care
    • Psychiatry and psychotherapy
    • Radiology
    • Forensic Medicine
    • Rheumatology
    • Sports Medicine
    • Traumatology and trauma surgery
    • Tropical and travel medicine
    • Urology
    • Dentistry
  • CME & Congresses
    • CME continuing education
    • Congress Reports
    • Congress calendar
  • Practice
    • Noctimed
    • Practice Management
    • Jobs
    • Interviews
  • Log In
  • Register
  • My account
  • Contact
  • English
    • Deutsch
    • Français
    • Italiano
    • Português
    • Español
  • Publications
  • Contact
  • Deutsch
  • English
  • Français
  • Italiano
  • Português
  • Español
Subscribe
Medizinonline Medizinonline
Medizinonline Medizinonline
  • News
    • News
    • Market & Medicine
  • Patienten
    • Krankheitsbilder
    • Diagnostik
    • Therapie
  • Partner Content
    • Dermatology
      • Atopic dermatitis and psoriasis news
      • Dermatology News
    • Diabetes
      • Dia-Month Club – Type 2 Diabetes
      • Diabetes in Motion
      • Diabetes Podcasts
    • Gastroenterology
      • IBD matters
      • Forum Gastroenterology
      • Ozanimod: ulcerative colitis
      • Reflux Update
    • Immunology
      • Primary immunodeficiency – exchange of experience
    • Vaccinate
      • Herpes zoster
    • Infektiologie
    • Neurology
      • EXPERT ULTRASONIC: Introduction to ultrasound-guided injection
      • MS News
      • MS Therapy in Transition
    • Oncology
      • Swiss Oncology in motion
    • Orthopedics
      • Osteoporosis in motion
    • Phytotherapie
    • Practice Management
      • Aargau Cantonal Bank
      • Claraspital
    • Psychiatry
      • Geriatric Psychiatry
    • Rheumatology
  • Departments
    • Fachbereiche 1-13
      • Allergology and clinical immunology
      • General Internal Medicine
      • Anesthesiology
      • Angiology
      • Surgery
      • Dermatology and venereology
      • Endocrinology and Diabetology
      • Nutrition
      • Gastroenterology and Hepatology
      • Genetics
      • Geriatrics
      • Gynecology
      • Hematology
    • Fachbereiche 14-26
      • Infectiology
      • Cardiology
      • Nephrology
      • Neurology
      • Emergency and intensive care medicine
      • Nuclear Medicine
      • Oncology
      • Ophthalmology
      • ORL
      • Orthopedics
      • Pediatrics
      • Pharmacology and toxicology
      • Pharmaceutical medicine
    • Fachbereiche 26-38
      • Phlebology
      • Physical medicine and rehabilitation
      • Phytotherapy
      • Pneumology
      • Prevention and health care
      • Psychiatry and psychotherapy
      • Radiology
      • Forensic Medicine
      • Rheumatology
      • Sports Medicine
      • Traumatology and trauma surgery
      • Tropical and travel medicine
      • Urology
      • Dentistry
  • CME & Congresses
    • CME continuing education
    • Congress Reports
    • Congress calendar
  • Practice
    • Noctimed
    • Practice Management
    • Jobs
    • Interviews
Login

Sie haben noch keinen Account? Registrieren

  • Vertigo

Ginkgo biloba contributes to central vestibular compensation

    • Education
    • General Internal Medicine
    • Geriatrics
    • Neurology
    • ORL
    • Pharmaceutical medicine
    • RX
    • Studies
  • 3 minute read

In central vestibular vertigo, errors occur in processing information to maintain balance and stabilize gaze due to lesions in the brainstem or cerebellum. The treatment includes, among others, physiotherapeutic and medicinal measures. An exploratory clinical trial published in 2022 demonstrated that the use of a special Ginkgo extract in combination with balance training significantly improved symptoms.

The most common causes of central vestibular dizziness are strokes, neurodegenerative diseases or tumors. Common consequences are gait instability and increased risk of falls [1–3]. This can be explained by the fact that vestibular disorders lead to sensory conflict. However, symptoms can be relieved by central vestibular compensation. This compensation is associated with CNS plasticity [4].

The ginkgo special extract EGb 761® has been shown to be effective in the treatment of various forms of vertigo [5,6]. The various constituents of Ginkgo biloba exert multimodal efficacy, including improving mitochondrial function, which has a beneficial effect on ATP production, and this in turn stimulates neuroplasticity [7]. In addition, EGb 761® has blood circulation-enhancing effects in the brain, which contributes to better microcirculation.

In a study published in the journal Neuroscience and Medicine , the effects of a combination of balance training with EGb 761® were investigated in patients with central vertebral dizziness.

Greater improvement in vertigo symptoms in ginkgo group

The randomized, placebo-controlled, double-blind study conducted at the University Hospital of Lübeck (D) included 40 patients aged 30-75 years [6]. Patients suffered from central vestibular vertigo due to ischemic lesions in the brainstem or cerebellum. Vertigo symptoms were quantified on a scale of 0 to 35 in terms of intensity, frequency, and duration. The inclusion criterion was a score of at least 5. Patients were treated with 2× 120 mg EGb 761®/d or placebo for 180 days and performed a standardized program of vestibular exercises daily. The primary endpoint was patient assessment of the severity of vertigo symptoms. A visual analog scale (VAS) was used for this purpose, with scores ranging from 0 (=no complaints) to 100 (= most severe complaints). In addition, the assessment of vertigo symptoms from the physician’s point of view was surveyed, using a scale with values from 1 (=return to normal) to 6 (=significant worsening). Eye movement parameters and patient-rated intensity, duration, and frequency of vertigo symptoms were chosen as secondary endpoints (using the 0 to 35 scale for participant selection).

Analyses showed that at day 180 after baseline, patient-assessed vertigo severity (VAS) (Fig. 1) improved by 46% in the EGb 761® group, compared with 19% in the placebo group [6]. A significant difference between the two groups was evident by day 60. Regarding physician assessment, there was a trend toward greater improvement under EGb 761® vs. placebo. For the secondary endpoints, the dizziness score at day 180 showed a statistically significant benefit (p=0.04) for the EGb 761® group. Throughout the study period, EGb 761® proved to be well tolerated.

Literature:

  1. Kammerlind AS, Håkansson JK, Skogsberg MC: Effects of balance training in elderly people with nonperipheral vertigo and unsteadiness. Clin Rehabil 2001; 15(5): 463-470.
  2. Schlick C, et al: Falls and fear of falling in vertigo and balance disorders: A controlled cross-sectional study. Journal of Vestibular Research 2016; 25(5-6): 241-251.
  3. Alyono JC: Vertigo and dizziness. Otolaryngologic Clinics of North America 2018; 51(4): 725-740.
  4. “Vertigo in Family Practice,” www.arztakademie.at/fileadmin/template/main/
    geriatrics/publications19/Sakho-Brehm_Svertigo_in_family_physician_practice_FINAL.pdf
    , (last accessed Oct 04, 2023).
  5. Drug Information, www.swissmedicinfo.ch,(last accessed Oct. 04, 2023).
  6. Heide W, et al: Ginkgo biloba Extract EGb 761® Improves Central Vestibular Vertigo in Patients Undergoing Vestibular Exercises: A Randomised Placebo-Controlled Trial. Neuroscience and Medicine 2022, www.scirp.org/journal/paperinformation,(last accessed Oct. 04, 2023).
  7. Müller WE, Heiser J, Leuner K: Effects of the standardized Ginkgo biloba extract EGb761® on neuroplasticity. Int Psychogeriatr 2012; 24(Suppl 1): S21-24.

HAUSARZT PRAXIS 2023; 18(10): 23

Autoren
  • Mirjam Peter, M.Sc.
Publikation
  • HAUSARZT PRAXIS
Related Topics
  • Balance
  • Dizziness
  • Ginkgo biloba
  • VERTIGo
Previous Article
  • Fact or fiction

The role of the psyche in irritable bowel syndrome in interdisciplinary therapy management.

  • CME continuing education
  • Gastroenterology and Hepatology
  • Psychiatry and psychotherapy
  • RX
  • Studies
View Post
Next Article
  • Teledermatology

Evaluation of patient satisfaction

  • Allergology and clinical immunology
  • Dermatology and venereology
  • General Internal Medicine
  • Practice Management
  • Prevention and health care
  • RX
View Post
You May Also Like
View Post
  • 4 min
  • Case report: Drug-induced hepatitis

Rare side effect of tirzepatide therapy

    • Cases
    • Education
    • Endocrinology and Diabetology
    • Gastroenterology and Hepatology
    • Pharmacology and toxicology
    • RX
    • Studies
View Post
  • 4 min
  • Plea for sex-specific neurology

Migraine in men: underdiagnosed, underestimated, under-researched

    • Education
    • Neurology
    • RX
    • Studies
View Post
  • 4 min
  • Prurigo nodularis

Retrospective analyses of large data sets from everyday practice

    • Allergology and clinical immunology
    • Congress Reports
    • Dermatology and venereology
    • RX
View Post
  • 3 min
  • Public Health

Outpatient care in Switzerland: situation report

    • General Internal Medicine
    • Practice Management
    • Prevention and health care
    • RX
View Post
  • 5 min
  • Practice Management

Improved quality of care aims for satisfied patients

    • CME continuing education
    • General Internal Medicine
    • Practice Management
    • Prevention and health care
    • RX
    • Studies
View Post
  • 30 min
  • Chemsex - MSM, sex, chrystal meth & co.

Medical and psychosocial perspectives

    • CME continuing education
    • General Internal Medicine
    • Infectiology
    • Pharmacology and toxicology
    • Prevention and health care
    • Psychiatry and psychotherapy
    • RX
View Post
  • 3 min
  • Bladder cancer

Tuberculosis vaccination reduces recurrences

    • Congress Reports
    • Oncology
    • Pneumology
    • Prevention and health care
    • RX
    • Studies
    • Urology
View Post
  • 4 min
  • Oral JAK-i in atopic dermatitis

Benefits and risks: What does the current data say?

    • Allergology and clinical immunology
    • Congress Reports
    • Dermatology and venereology
    • RX
    • Studies
Top Partner Content
  • Forum Gastroenterology

    Zum Thema
  • Herpes zoster

    Zum Thema
  • Dermatology News

    Zum Thema
Top CME content
  • 1
    Patience, knowledge and persistence in therapy
  • 2
    Sarcopenia and malnutrition in the context of pneumological rehabilitation
  • 3
    Medical and psychosocial perspectives
  • 4
    New nomenclature for non-alcoholic fatty liver disease
  • 5
    Examinations and considerations before therapy

Newsletter

Sign up and stay up to date

Subscribe
Medizinonline
  • Contact
  • General terms and conditions
  • Imprint

Input your search keywords and press Enter.