Over time, fluctuations in efficacy may occur in Parkinson’s therapy with L-dopa. Then, the treatment of L-dopa induced dyskinesias and motor fluctuations represents the most important task in clinical practice. Additional blockade of COMT may result in a prolongation of the L-dopa half-life and an increase in bioavailability.
Autoren
- em.o. Univ. Prof. Dr. Werner Poewe
Publikation
- InFo NEUROLOGIE & PSYCHIATRIE
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