Biologics and JAK-i – the best of both worlds

In Switzerland, both the currently approved monoclonal antibodies (dupilumab, tralokinumab, lebrikizumab) and the Janus kinase (JAK) inhibitors (baricitinib, abro-citinib, upadacitinib) can be used as “first-line” systemic therapy for patients with atopic dermatitis after an inadequate response to topical treatment. The choice is therefore large – making the question of subjective and objective decision criteria all the more important.