Brain atrophy correlates with disability progression in MS

Brain atrophy in MS patients, particularly in the thalamus, correlates strongly with long-term physical disability and cognitive deficits. A long-term analysis of the phase 3 studies RADIANCE/SUNBEAM and the open-label extension DAYBREAK now examines the efficacy of ozanimod over seven years. The results confirm sustained protection against volume loss and highlight the predictive role of brain volume biomarkers.