Using data from the longitudinal “UK Biobank” initiated in the pre-pandemic era, cerebral MRI findings before and after COVID-19 were collected for the first time in the same individuals and compared with a control group of uninfected individuals [1]. As a result, intermediate SARS-CoV-2 infected individuals showed a decrease in gray matter in the orbitofrontal cortex and a decrease in total brain mass. In those affected, cognitive test scores also deteriorated over time. Whether these changes are reversible is currently an open question. Another study [2] showed an increased rate of de novo dementia after COVID-19 compared with other pneumonias.