Medizinonline Medizinonline
  • News
    • News
    • Market & Medicine
  • Patients
    • Disease patterns
    • Diagnostics
    • Therapy
  • Partner Content
    • Dermatology
      • Atopic dermatitis and psoriasis news
      • Dermatology News
    • Diabetes
      • Dia-Month Club – Type 2 Diabetes
      • Diabetes in Motion
      • Diabetes Podcasts
    • Gastroenterology
      • IBD matters
      • Forum Gastroenterology
      • Ozanimod: ulcerative colitis
      • Reflux Update
    • Immunology
      • Primary immunodeficiency – exchange of experience
    • Vaccinate
      • Herpes zoster
    • Infektiologie
    • Neurology
      • EXPERT ULTRASONIC: Introduction to ultrasound-guided injection
      • MS News
      • MS Therapy in Transition
    • Oncology
      • Swiss Oncology in motion
    • Orthopedics
      • Osteoporosis in motion
    • Phytotherapie
    • Practice Management
      • Aargau Cantonal Bank
      • Claraspital
    • Psychiatry
      • Geriatric Psychiatry
    • Rheumatology
  • Departments
    • Allergology and clinical immunology
    • General Internal Medicine
    • Anesthesiology
    • Angiology
    • Surgery
    • Dermatology and venereology
    • Endocrinology and Diabetology
    • Nutrition
    • Gastroenterology and Hepatology
    • Genetics
    • Geriatrics
    • Gynecology
    • Hematology
    • Infectiology
    • Cardiology
    • Nephrology
    • Neurology
    • Emergency and intensive care medicine
    • Nuclear Medicine
    • Oncology
    • Ophthalmology
    • ORL
    • Orthopedics
    • Pediatrics
    • Pharmacology and toxicology
    • Pharmaceutical medicine
    • Phlebology
    • Physical medicine and rehabilitation
    • Pneumology
    • Prevention and health care
    • Psychiatry and psychotherapy
    • Radiology
    • Forensic Medicine
    • Rheumatology
    • Sports Medicine
    • Traumatology and trauma surgery
    • Tropical and travel medicine
    • Urology
    • Dentistry
  • CME & Congresses
    • CME continuing education
    • Congress Reports
    • Congress calendar
  • Practice
    • Noctimed
    • Practice Management
    • Jobs
    • Interviews
  • Log In
  • Register
  • My account
  • Contact
  • English
    • Deutsch
    • Français
    • Italiano
    • Português
    • Español
  • Publications
  • Contact
  • Deutsch
  • English
  • Français
  • Italiano
  • Português
  • Español
Subscribe
Medizinonline Medizinonline
Medizinonline Medizinonline
  • News
    • News
    • Market & Medicine
  • Patienten
    • Krankheitsbilder
    • Diagnostik
    • Therapie
  • Partner Content
    • Dermatology
      • Atopic dermatitis and psoriasis news
      • Dermatology News
    • Diabetes
      • Dia-Month Club – Type 2 Diabetes
      • Diabetes in Motion
      • Diabetes Podcasts
    • Gastroenterology
      • IBD matters
      • Forum Gastroenterology
      • Ozanimod: ulcerative colitis
      • Reflux Update
    • Immunology
      • Primary immunodeficiency – exchange of experience
    • Vaccinate
      • Herpes zoster
    • Infektiologie
    • Neurology
      • EXPERT ULTRASONIC: Introduction to ultrasound-guided injection
      • MS News
      • MS Therapy in Transition
    • Oncology
      • Swiss Oncology in motion
    • Orthopedics
      • Osteoporosis in motion
    • Phytotherapie
    • Practice Management
      • Aargau Cantonal Bank
      • Claraspital
    • Psychiatry
      • Geriatric Psychiatry
    • Rheumatology
  • Departments
    • Fachbereiche 1-13
      • Allergology and clinical immunology
      • General Internal Medicine
      • Anesthesiology
      • Angiology
      • Surgery
      • Dermatology and venereology
      • Endocrinology and Diabetology
      • Nutrition
      • Gastroenterology and Hepatology
      • Genetics
      • Geriatrics
      • Gynecology
      • Hematology
    • Fachbereiche 14-26
      • Infectiology
      • Cardiology
      • Nephrology
      • Neurology
      • Emergency and intensive care medicine
      • Nuclear Medicine
      • Oncology
      • Ophthalmology
      • ORL
      • Orthopedics
      • Pediatrics
      • Pharmacology and toxicology
      • Pharmaceutical medicine
    • Fachbereiche 26-38
      • Phlebology
      • Physical medicine and rehabilitation
      • Phytotherapy
      • Pneumology
      • Prevention and health care
      • Psychiatry and psychotherapy
      • Radiology
      • Forensic Medicine
      • Rheumatology
      • Sports Medicine
      • Traumatology and trauma surgery
      • Tropical and travel medicine
      • Urology
      • Dentistry
  • CME & Congresses
    • CME continuing education
    • Congress Reports
    • Congress calendar
  • Practice
    • Noctimed
    • Practice Management
    • Jobs
    • Interviews
Login

Sie haben noch keinen Account? Registrieren

  • Parkinson's

Improving the effect of levodopa in the long term

    • Education
    • Geriatrics
    • Neurology
    • Pharmacology and toxicology
    • RX
  • 3 minute read

The treatment management of idiopathic Parkinson’s syndrome has improved significantly in recent years. Although a causal treatment is still not possible, the disease can now be treated symptomatically. In the meantime, different factors such as age, gender, leading symptoms and concomitant diseases can be addressed individually and the diminishing effect of levodopa can also be compensated for.

Idiopathic Parkinson’s syndrome is a neurodegenerative disease characterized by bradykinesia, rigidity, tremor and postural instability. The prevalence is 100 to 200 per 100,000 inhabitants. Pathologically, a degeneration of dopaminergic neurons in the substantia nigra plays a significant role. What triggers neurodegeneration is mostly unknown. An impaired degradation of misfolded α-synuclein in lysosomes, but also a dysfunction of the mitochondria seem to be involved. Genetics can play a role, but is the sole cause in less than 10% of patients. Mutations in the glucocerebrosidase gene increase the risk, while mutations in the α-synuclein gene, for example PARK1, can be directly disease-causing. The typical symptoms are preceded by a long prodomal phase, during which other symptoms such as odor or sleep disorders can occur. Only when at least half of the neurons have died and the dopamine content in the corpus striatum is reduced by at least two thirds do the typical Parkinson’s symptoms appear.

Dopamine agonists drug of choice

To date, there is no curative treatment available for Parkinson’s disease. Therapeutically, the aim is therefore to improve the quality of life with an improvement in motor, autonomic, cognitive and psychiatric symptoms and to avoid secondary complications and side effects of dopaminergic treatment. This is because the disease is characterized by cardinal motor symptoms due to a dopamine deficit, especially in the early stages, so that treatment management is mainly based on the administration of dopaminergically active substances. For younger patients in particular, the guideline recommends the use of dopamine agonists or an MAO-B inhibitor as monotherapy. However, patients who require levodopa from the outset should also receive it right at the start of therapy. Levodopa is a precursor of dopamine which, unlike dopamine, can cross the blood-brain barrier. In the CNS, levodopa is converted into dopamine by enzymatic decarboxylation. However, degradation also takes place in the periphery, so that only a fraction of the amount of levodopa administered orally reaches the CNS. For this reason, it is always combined with one of the two peripherally active dopa decarboxylase inhibitors (DDI) carbidopa or benserazide when administered orally. However, after around five years of treatment, motor fluctuations are generally to be expected. To counteract end-of-dose hypokinesia, for example, catechol-O-methyltransferase (COMT) inhibitors can be used to inhibit the breakdown of L-dopa to 3-O-methyldopa.

The first inhibitors to be introduced for add-on therapy were tolcapone and entacapone. Opicapon is now also available as a preparation that only needs to be taken once a day. All preparations are only effective in combination with levodopa and are given in combination with levodopa and one of the DDIs. It is important to adjust the original leodopa dose at the start of therapy in order to avoid excessive reactions due to an increased dopamine concentration in the brain. Typical side effects such as dizziness, gastrointestinal complaints, muscle spasms, orthostasis with a drop in blood pressure, hallucinations, constipation and dyskinesia are therefore usually also due to the increased effect of dopamine.

Further reading:

  • Kalia LV, Lang AE. Parkinson’s disease. Lancet 2015; 386: 896-912.
  • www.pharmazeutische-zeitung.de/frueh-erkennen-gezielt-behandeln-144592/seite/5/?cHash=f96e22ce03b9342412e7d4a118b15b8d (letzter Zugriff am 31.03.2024)
  • www.akdae.de/fileadmin/user_upload/akdae/Arzneimitteltherapie/NA/Archiv/201703-Ongentys.pdf (last accessed on 31.03.2024)

InFo NEUROLOGY & PSYCHIATRY 2024; 22(2): 34

Autoren
  • Leoni Burggraf
Publikation
  • InFo NEUROLOGIE & PSYCHIATRIE
Related Topics
  • Dopamine agonists
  • Levodopa
  • Parkinson's
Previous Article
  • Heart failure: ESC guideline update 2023

Therapy-relevant new evidence on the entire EF spectrum

  • Cardiology
  • Congress Reports
  • General Internal Medicine
  • RX
  • Studies
View Post
Next Article
  • Cutaneous lupus erythematosus (CLE)

Assessment and outlook

  • Dermatology and venereology
  • Education
  • General Internal Medicine
  • RX
  • Studies
View Post
You May Also Like
View Post
  • 4 min
  • Case report: Drug-induced hepatitis

Rare side effect of tirzepatide therapy

    • Cases
    • Education
    • Endocrinology and Diabetology
    • Gastroenterology and Hepatology
    • Pharmacology and toxicology
    • RX
    • Studies
View Post
  • 4 min
  • Plea for sex-specific neurology

Migraine in men: underdiagnosed, underestimated, under-researched

    • Education
    • Neurology
    • RX
    • Studies
View Post
  • 4 min
  • Prurigo nodularis

Retrospective analyses of large data sets from everyday practice

    • Allergology and clinical immunology
    • Congress Reports
    • Dermatology and venereology
    • RX
View Post
  • 3 min
  • Public Health

Outpatient care in Switzerland: situation report

    • General Internal Medicine
    • Practice Management
    • Prevention and health care
    • RX
View Post
  • 5 min
  • Practice Management

Improved quality of care aims for satisfied patients

    • CME continuing education
    • General Internal Medicine
    • Practice Management
    • Prevention and health care
    • RX
    • Studies
View Post
  • 30 min
  • Chemsex - MSM, sex, chrystal meth & co.

Medical and psychosocial perspectives

    • CME continuing education
    • General Internal Medicine
    • Infectiology
    • Pharmacology and toxicology
    • Prevention and health care
    • Psychiatry and psychotherapy
    • RX
View Post
  • 3 min
  • Bladder cancer

Tuberculosis vaccination reduces recurrences

    • Congress Reports
    • Oncology
    • Pneumology
    • Prevention and health care
    • RX
    • Studies
    • Urology
View Post
  • 4 min
  • Oral JAK-i in atopic dermatitis

Benefits and risks: What does the current data say?

    • Allergology and clinical immunology
    • Congress Reports
    • Dermatology and venereology
    • RX
    • Studies
Top Partner Content
  • Forum Gastroenterology

    Zum Thema
  • Herpes zoster

    Zum Thema
  • Dermatology News

    Zum Thema
Top CME content
  • 1
    Patience, knowledge and persistence in therapy
  • 2
    Sarcopenia and malnutrition in the context of pneumological rehabilitation
  • 3
    Medical and psychosocial perspectives
  • 4
    New nomenclature for non-alcoholic fatty liver disease
  • 5
    Examinations and considerations before therapy

Newsletter

Sign up and stay up to date

Subscribe
Medizinonline
  • Contact
  • General terms and conditions
  • Imprint

Input your search keywords and press Enter.