Systemic Therapy for Patients with Comorbidities: What Is the Best Choice?

Psoriasis is a chronic inflammatory systemic disease often associated with comorbidities, a fact that must be taken into account during treatment. Particular attention should be paid to psoriatic arthritis (PsA), chronic inflammatory bowel diseases (IBD), obesity, and cardiometabolic diseases. These specific clinical situations pose a therapeutic challenge and require an individualized and interdisciplinary treatment strategy. The current S3 guideline, among other sources, provides many practice-relevant recommendations in this regard.