View Post 8 minute read This content is machine translated Benefits, limits and safety aspects Phytotherapy for cardiovascular diseases Cardiology Education Endocrinology and Diabetology General Internal Medicine Nutrition Pharmaceutical medicine Phytotherapy RX Studies Herbal preparations and “natural” dietary supplements are frequently used by patients with cardiovascular disease – often in the hope of “gently” influencing blood pressure, lipids or symptoms. However, guidelines from European and American professional societies unanimously emphasize that phytotherapeutics and dietary supplements should not replace established lifestyle and pharmacotherapy. In particular, the 2025 focused ESC/EAS update on dyslipidemia therapy concludes, after reviewing the available evidence, that there is insufficient evidence for any supplement that lowers LDL cholesterol while improving cardiovascular risk with reasonable safety…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt…
View Post 6 minute read This content is machine translated Results of the FOREST HCM study Symptomatic obstructive hypertrophic cardiomyopathy Cardiology Education RX Studies Myosin inhibition is considered a key therapeutic approach in the treatment of obstructive hypertrophic cardiomyopathy (oHCM). In addition to mavacamten, aficamten is now being clinically investigated as a potentially short-acting, specific myosin inhibitor. The FOREST-HCM study provides the first systematically collected 48-week data on efficacy, safety and functional changes under long-term treatment. The results provide relevant insights into the stability of gradient reduction, symptom control and tolerability of the drug in continuous use…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here
View Post 9 minute read This content is machine translated Neuroprotection, resilience and cognitive health in old age Longevity & Brain Education General Internal Medicine Geriatrics Neurology Prevention and health care RX Studies Cognitive health in old age is not an inevitable fate, but can be influenced to a relevant extent by modifiable factors. The Lancet Commission 2024 concludes that a significant proportion of dementia cases are potentially preventable or delayable over the course of a lifetime; the estimated proportion is around 45%. Elevated LDL cholesterol levels and untreated visual impairment are newly highlighted as relevant risk factors. At the same time, randomized trials have shown that structured multidimensional prevention programs can have a beneficial effect on cognitive trajectories, especially in people at increased risk (e.g. U.S. POINTER, JAMA 2025). Disease-modifying anti-amyloid antibodies are also available for early stages of Alzheimer’s disease, but their use is subject to…
View Post 6 minute read This content is machine translated Obesity as a chronic disease: an interdisciplinary perspective Neurobiological mechanisms of obesity Congress Reports General Internal Medicine Nutrition Prevention and health care Psychiatry and psychotherapy RX Studies A high-fat and high-sugar diet affects both the homeostatic hunger and satiety signals in the hypothalamus and the hedonic reward system, leading to persistent hunger and a strong craving for high-calorie foods. Chronic stress potentiates the negative effects of a high-fat diet and promotes weight gain through certain neuronal processes. Current data suggest that the neuronal changes are difficult to reverse, which explains the much-cited yo-yo effect and the difficulties in long-term weight maintenance…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here
View Post 5 minute read This content is machine translated Oncolytic virus in stage II melanoma Innovative method for predicting therapy response Dermatology and venereology Education Oncology RX Studies Until now, it was assumed that TVEC works by activating T cells. However, in a study by British and US scientists published in JCO Oncology Advances, the T cell populations showed no correlation with the success of the therapy. Instead, they found that changes in macrophages correlated with treatment response. Their pilot study used a FRET assay (iFRET), a novel tool for identifying biomarkers…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here
View Post 3 minute read This content is machine translated Phimosis and penile cancer under SGLT2i Increased risk for men with T2D Congress Reports Endocrinology and Diabetology General Internal Medicine RX Studies Urology In recent years, sodium-glucose cotransporter 2 inhibitors (SGLT2i) have been widely used in the treatment of type 2 diabetes, as they not only provide improved glycemic control, but also offer cardiovascular and nephroprotective benefits. However, SGLT2i cause glycosuria, which can lead to infection and inflammation in the microenvironment of the foreskin. To date, very little data is available on the risk of these specific complications…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here
View Post 12 minute read This content is machine translated Diabetic ketoacidosis Recommendations for action in practice Cases CME continuing education Emergency and intensive care medicine Endocrinology and Diabetology Hematology Nephrology RX Diabetic ketoacidosis (DKA) is an acutely life-threatening complication of diabetes mellitus that occurs predominantly in type 1 diabetes, but is also increasingly occurring in people with type 2 diabetes. A special form is euglycemic DKA, which mainly occurs during therapy with SGLT2 inhibitors. Even though it has become rare and the mortality rate is now only just over 1%, these deaths are usually preventable. Timely diagnosis, standardized treatment protocols and, above all, prophylaxis are crucial for the prognosis…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here CME-Test
View Post 6 minute read This content is machine translated Migraine: better quality of life thanks to multimodal care Broader selection of innovative migraine prophylactics and acute therapies Congress Reports Neurology Pharmacology and toxicology RX Studies The fact that migraine therapy is changing is also reflected in the recent publication of the updated S1 guideline “Treatment of migraine attacks and prophylaxis of migraine”. Although triptans are still the standard medication for treating acute migraine attacks, new active ingredients are expanding the treatment arsenal. Progress has also been made in migraine prophylaxis – for example, two new oral CGRP receptor antagonists have established themselves as treatment alternatives. These are just some of the innovations that should contribute to optimized care for migraine patients…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here
View Post 4 minute read This content is machine translated Therapy of non-tumor-related pain Do not prescribe opioids lightly for musculoskeletal pain General Internal Medicine Pharmacology and toxicology Prevention and health care RX Studies A UK research team used electronic primary care patient records from 2006-2021 based on the Clinical Research Practice Datalink (CPRD) to identify opioid prescriptions. The analyses revealed that almost three quarters of all new opioid prescriptions were for patients with musculoskeletal conditions. The results were published in the journal Pain in 2025. Specific recommendations for the management of non-tumor-related chronic pain in the GP setting can be found in the current German-language DEGAM guideline, among others…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here
View Post 14 minute read This content is machine translated "Forgotten axis" between plant substances, gut and systemic health Microbiome and phytotherapy Education Endocrinology and Diabetology Gastroenterology and Hepatology General Internal Medicine Infectiology Neurology Nutrition Pharmaceutical medicine Phytotherapy RX Studies In recent years, the intestinal microbiome has developed from a marginal phenomenon to a central topic in immunology, metabolic medicine, neuroscience and oncology. Dysbiosis is associated with obesity, type 2 diabetes, cardiovascular disease, chronic inflammatory bowel disease, autoimmunity and neuropsychiatric disorders. At the same time, the importance of active plant substances – dietary fibers, polyphenols, bitter substances, essential oils – as modulators of intestinal ecology is coming into focus. The article outlines the role of the microbiome in health and disease and highlights the extent to which phytotherapy and plant-based interventions intervene in this system in an evidence-based manner…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische…
Patient-centered rounds in medicine Aligning care with the patient CME continuing education Education General Internal Medicine Prevention and health care RX Studies View Post
Findings from the ALS Symposium 2024 in Montreal Current and future approaches in the treatment of amyotrophic lateral sclerosis (ALS) CME continuing education Congress Reports Interviews Neurology RX Studies View Post
Findings from the ALS Symposium 2024 in Montreal Current and future approaches in the treatment of amyotrophic lateral sclerosis (ALS) Congress Reports Interviews Neurology RX Studies View Post
Artificial intelligence in medicine Opportunities and risks of AI RX CME continuing education Dermatology and venereology Education General Internal Medicine Prevention and health care View Post
Artificial intelligence in medicine Opportunities and risks of AI RX CME continuing education Dermatology and venereology Education General Internal Medicine Prevention and health care View Post
Patient-centered rounds in medicine Aligning care with the patient RX CME continuing education Education General Internal Medicine Prevention and health care Studies View Post
Thyroid Diseases Clarification of thyroid nodules RX CME continuing education Education Endocrinology and Diabetology General Internal Medicine Nuclear Medicine Oncology Radiology View Post
Patient-centered rounds in medicine Aligning care with the patient RX CME continuing education Education General Internal Medicine Prevention and health care Studies View Post
Patient-centered rounds in medicine Aligning care with the patient RX CME continuing education Education General Internal Medicine Prevention and health care Studies View Post
Advanced urothelial carcinoma of the urinary bladder Systemic therapy RX CME continuing education Education Oncology Studies Urology View Post
View Post This content is machine translated Diabetic ketoacidosis Recommendations for action in practice Cases CME continuing education Emergency and intensive care medicine Endocrinology and Diabetology Hematology Nephrology RX Diabetic ketoacidosis (DKA) is an acutely life-threatening complication of diabetes mellitus that occurs predominantly in type 1 diabetes, but is also increasingly occurring in people with type 2 diabetes. A special form is euglycemic DKA, which mainly occurs during therapy with SGLT2 inhibitors. Even though it has become rare and the mortality rate is now only just over 1%, these deaths are usually preventable. Timely diagnosis, standardized treatment protocols and, above all, prophylaxis are crucial for the prognosis…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here CME-Test
View Post This content is machine translated Psychooncology Communication as the key to therapy adherence CME continuing education General Internal Medicine Practice Management RX Patient satisfaction and adherence depend crucially on the doctor-patient discussion. Communication skills are usually the key to success here. Good interview conditions, sufficient time and an empathetic approach to the diagnosis…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here CME-Test
View Post This content is machine translated AI in neurology Control instead of a flood of data: AI makes big data and wearables usable Cardiology CME continuing education General Internal Medicine Neurology Prevention and health care RX Studies Artificial intelligence has become a key technology in medicine, including in complex neurology. Modern methods such as machine learning and deep learning in combination with data and wearables (wearable sensor technology) enable more precise diagnostics, prognoses and treatment decisions…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here CME-Test
View Post This content is machine translated Artificial intelligence Dr. ChatGPT: Large language models in everyday clinical practice Cases CME continuing education General Internal Medicine Prevention and health care RX With the public availability of ChatGPT 3.5 in fall 2022 at the latest, artificial intelligence in the sense of large language models (LLMs) is on everyone’s lips. However, it is often forgotten that this is only the provisional end point of decades of development of artificial intelligence, which, despite its great potential, still has many limitations. The question for practising doctors is how this technology can be used sensibly in everyday clinical practice – and how it should not be used…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here CME-Test
