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  • 5 minute read
  • This content is machine translated Mental Health with GLP-1 RAs

Benefits of Semaglutide and Liraglutide

GLP-1 receptor agonists are established treatments for type 2 diabetes and obesity. Depression and anxiety disorders are common among people with diabetes and obesity, and both conditions are associated with an increased risk of psychiatric morbidity, illness-related absenteeism, self-harm, and suicide. The potential effects of GLP-1 RAs on mental health remain controversial…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here
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  • 4 minute read
  • This content is machine translated Bronchiolitis obliterans

Out of shape even without popcorn

Post-infectious bronchiolitis obliterans (PIBO) develops in childhood and is characterized by irreversible airway obstruction and persistent impairment of lung function. Although it is known that exercise capacity may be impaired, cardiorespiratory fitness (CRF) in pediatric PIBO remains poorly defined…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here
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  • 8 minute read
  • This content is machine translated Case study

Guillain-Barré syndrome with a fulminant course

A 38-year-old male patient experienced a transient loss of all brainstem reflexes as part of an unusual course of Guillain-Barré syndrome, which, despite preserved cortical functions, resembled a coma or brain death. As treatment progressed, his condition gradually improved. This demonstrates that early diagnosis, the exclusion of central causes, and timely immunotherapy can lead to significant neurological recovery even in the most severe cases of Guillain-Barré syndrome…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here
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  • 5 minute read
  • This content is machine translated Suspicion of neuroborreliosis?

Detection of borrelia-specific CSF parameters provides certainty

A neurological manifestation occurs in 3-15% of Lyme borreliosis infections and can manifest itself, for example, as polyradiculitis, meningitis or, in rare cases, encephalomyelitis. If neuroborreliosis is suspected, it is recommended that serum and cerebrospinal fluid tests are carried out, as the detection of borrelia-specific intrathecal antibody synthesis in conjunction with inflammatory changes in the cerebrospinal fluid is conclusive. Neuroborreliosis can be treated with antibiotics…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here
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  • 12 minute read
  • This content is machine translated The Brain and the Motivation to Eat

Why is it so hard to lose weight?

Obesity is the most common chronic disease in Western societies, with serious metabolic, cardiovascular, and psychosocial consequences. The therapeutic landscape has changed fundamentally: new-generation GLP-1 agonists achieve weight loss that, just a few years ago, was reserved solely for bariatric surgery. This presents physicians with a clear task: to understand obesity as a biologically based chronic disease and to treat it accordingly…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here
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  • 12 minute read
  • This content is machine translated Global Recommendation, Swissmedic Approval, and SL Limitation

WHO Guidelines on GLP-1 for Obesity

With the guideline published on December 1, 2025, the World Health Organization has, for the first time, issued a globally applicable recommendation on the pharmacological management of obesity in adults. It was released simultaneously with an accompanying article in the Journal of the American Medical Association. This is more than just a technical update: The WHO thereby explicitly recognizes obesity as a chronic, recurrent disease that—similar to hypertension or diabetes—requires long-term, structured treatment. For general practice, diabetes care, and cardiology practices, the question is therefore less whether GLP-1-based therapies have a place, and more about for whom, under what circumstances, and with what responsibilities they should be used…. Dieser Inhalt ist nur für…
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  • 7 minute read
  • This content is machine translated Obesity in Children and Adolescents

Gene-Environment Interactions: Polygenic or Monogenic Determinants?

In the context of precision medicine, a differentiated approach to the diagnosis of obesity provides an essential foundation for implementing improved strategies for prevention, treatment, and prognosis. Obesity is often caused by a polygenic disorder of energy regulation, but there are also rare monogenic and syndromic forms of obesity that arise as early as infancy due to a lack of satiety. Like other chronic diseases, obesity requires long-term medical care—a multimodal treatment approach is most likely to be successful…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here
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  • 9 minute read
  • This content is machine translated Congenital Vascular Malformations

Personalized Treatment Before a Planned Pregnancy

Vascular malformations have a prevalence of 1% and an incidence of 3–5 per 10,000. Anomalies can affect any organ system in children and adults. Mosaic mutations occurring during embryonic development lead to a segmental defect in the development of the vascular system, affecting the veins, arteries, lymphatic vessels, or a combination of all three…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here
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  • 18 minute read
  • This content is machine translated From Risk Identification to Anti-Inflammatory Intervention

Inflammation as a Treatment Goal in Its Own Right

For decades, cardiovascular prevention was essentially a story about cholesterol. Yet a significant proportion of patients experience adverse events despite optimally controlled lipid levels—a reflection of a residual risk that is increasingly attributed to inflammation. The ORFAN study visualizes coronary inflammation on CT scans, IL-6 and high-sensitivity CRP (hsCRP) have proven to be powerful prognostic markers, and Paul Ridker’s concept of “SMuRF-less but inflamed” patients demonstrates that inflammation poses a risk even in the absence of classic risk factors. From detection, the path leads to intervention—with colchicine as the first approved anti-inflammatory agent and targeted cytokine blockade on the horizon…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische…
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  • 6 minute read
  • This content is machine translated Liver Cancer

Artificial Intelligence in Precision Oncology—Opportunities and Challenges

The 2025 ESMO Congress covered a wide range of translational and clinical topics, with the growing importance of artificial intelligence (AI) in diagnosis, prognosis, and treatment decisions standing out in particular. In his presentation titled “AI in Precision Oncology of Liver Cancer,” Prof. Julien Calderaro (Henri Mondor University Hospital, Créteil) presented the latest findings on the use of AI-based methods in precision oncology for liver cancer and highlighted diagnostic, prognostic, and treatment-related aspects…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here
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View Post
  • This content is machine translated The Brain and the Motivation to Eat

Why is it so hard to lose weight?

Obesity is the most common chronic disease in Western societies, with serious metabolic, cardiovascular, and psychosocial consequences. The therapeutic landscape has changed fundamentally: new-generation GLP-1 agonists achieve weight loss that, just a few years ago, was reserved solely for bariatric surgery. This presents physicians with a clear task: to understand obesity as a biologically based chronic disease and to treat it accordingly…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here
CME-Test
View Post
  • This content is machine translated Congenital Vascular Malformations

Personalized Treatment Before a Planned Pregnancy

Vascular malformations have a prevalence of 1% and an incidence of 3–5 per 10,000. Anomalies can affect any organ system in children and adults. Mosaic mutations occurring during embryonic development lead to a segmental defect in the development of the vascular system, affecting the veins, arteries, lymphatic vessels, or a combination of all three…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here
CME-Test
View Post
  • This content is machine translated From Risk Identification to Anti-Inflammatory Intervention

Inflammation as a Treatment Goal in Its Own Right

For decades, cardiovascular prevention was essentially a story about cholesterol. Yet a significant proportion of patients experience adverse events despite optimally controlled lipid levels—a reflection of a residual risk that is increasingly attributed to inflammation. The ORFAN study visualizes coronary inflammation on CT scans, IL-6 and high-sensitivity CRP (hsCRP) have proven to be powerful prognostic markers, and Paul Ridker’s concept of “SMuRF-less but inflamed” patients demonstrates that inflammation poses a risk even in the absence of classic risk factors. From detection, the path leads to intervention—with colchicine as the first approved anti-inflammatory agent and targeted cytokine blockade on the horizon…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische…
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  • This content is machine translated Psychooncology

Communication as the key to therapy adherence

Patient satisfaction and adherence depend crucially on the doctor-patient discussion. Communication skills are usually the key to success here. Good interview conditions, sufficient time and an empathetic approach to the diagnosis…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here
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