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Endometrial carcinoma

Endometrial carcinoma was long considered the “benign” type among gynecological malignancies: it presents with symptoms early, is usually diagnosed at Stage I, and is curable by surgery. This characterization remains true for the majority of patients. For the minority with advanced or recurrent disease, however, almost everything has changed within just a few years. Molecular classification has evolved from a research tool to the standard for treatment planning; the FIGO classification has incorporated molecular parameters into its staging system, and the combination of chemotherapy and checkpoint inhibition has produced survival curves in the mismatch repair-deficient subgroup that were previously unknown for this entity. Version 4 of the S3 guideline, published in May 2026 and…
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Clinical Presentation, Diagnosis, and Treatment of DSPN

Distal symmetric sensorimotor polyneuropathy (DSPN) is the most common form of diabetic neuropathy. About one-third of all diabetes patients are affected by it. They often develop neuropathic pain, although a significant proportion remain completely symptom-free, at least at times—it is precisely these painless courses that are insidious, because they progress unnoticed toward a loss of sensation…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here
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Why is it so hard to lose weight?

Obesity is the most common chronic disease in Western societies, with serious metabolic, cardiovascular, and psychosocial consequences. The therapeutic landscape has changed fundamentally: new-generation GLP-1 agonists achieve weight loss that, just a few years ago, was reserved solely for bariatric surgery. This presents physicians with a clear task: to understand obesity as a biologically based chronic disease and to treat it accordingly…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here
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Development, Diagnosis, Epidemiology, and Treatment of a Disease Entity

According to the 2010 and 2011 ACR diagnostic criteria, as revised in 2016, fibromyalgia syndrome is a multisymptomatic disorder whose primary symptom is chronic tendon-muscle pain that shifts and spreads widely across the body. This is accompanied by sleep disturbances, waking up feeling unrested, fatigue, and a possible variety of other, predominantly psychovegetative symptoms…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here