This content is machine translated Study report: Nicotinamide for skin cancer prevention Cohort study analyzed data from over 30,000 patients In the US cohort study published in JAMA Dermatology 2025, the risk of non-melanocytic skin cancer (NMSC) was reduced in patients who had received nicotinamide supplementation – especially if the...…
View Post 9 min This content is machine translated Evidence, pathophysiology and management in the light of current data Heart failure with improved ejection fraction (HFimpEF) In recent years, Heart Failure with Improved Ejection Fraction (HFimpEF) has developed into a clinical entity in its own right, which is being considered in an increasingly differentiated manner. With...…
View Post 5 min This content is machine translated Early rheumatoid arthritis C1M has potential as a biomarker The earlier rheumatoid arthritis (RA) is diagnosed, the better the prognosis. But easier said than done. Conventional clinical, serological and imaging markers often lack sufficient sensitivity in the early stages...…
View Post 7 min This content is machine translated Longevity Medicine 2025 From anti-ageing to precision prevention Longevity Medicine in 2025 is less a marketing term than a clinical work program: moving away from fuzzy “anti-aging” promises towards measurable risk, biomarker and intervention logic. Drivers are a...…
View Post 7 min This content is machine translated Pathophysiology, clinical significance and therapeutic consequences Eosinophils in asthma For a long time, eosinophils were regarded as the central effector cells of asthma and were interpreted in the classical model as a direct damaging agent of the epithelium, as...…
View Post 12 min This content is machine translated Urothelial carcinoma Perioperative innovations and organ-preserving strategies Urothelial carcinoma is an aggressive tumor entity with high morbidity. In recent years, the perioperative treatment spectrum – particularly for muscle-invasive bladder cancer – has expanded significantly: Immune checkpoint inhibitors...…
View Post 9 min This content is machine translated Microbiome, inflammaging and affective/cognitive health Gut-brain axis in old age As we age, the composition and function of the gut microbiome, the integrity of the intestinal barrier and systemic immune regulation change. These changes are closely linked to the concept...…
View Post 4 min This content is machine translated From symptom to diagnosis Abdominal pain – external hernias If the hernia can be seen from the outside or if the protrusion resulting from a hernia leads from the inside of the body towards the skin, it is referred...…
View Post 6 min This content is machine translated What biomarkers reveal about "biological youth" - and what not (yet) Epigenetic ageing In recent years, epigenetic clocks based on DNA methylation have evolved from research tools to widely used biomarkers of biological ageing. They correlate not only with chronological age, but also...…
View Post 10 min This content is machine translated Mechanisms, evidence and therapeutic consequences GLP-1 receptor agonists in cardiology GLP-1 receptor agonists (GLP-1RAs) have rapidly evolved from antidiabetic drugs to cardiometabolic therapies with clinically proven reductions in hard cardiovascular endpoints – and increasingly beyond the traditional diabetes population. The...…
View Post 6 min This content is machine translated New ways of neuroregeneration CRISPR and artificial intelligence The combination of precise genome editing using CRISPR and AI-supported modeling of complex CNS damage marks a paradigm shift in neuroregeneration. Adaptive, closed therapy loops are designed to address multiple...…
