This content is machine translated Ginkgo biloba extract in the Alzheimer's mouse model Effects on disease-associated microglia subpopulations During the progression of Alzheimer’s disease, microglial cells located in the vicinity of plaques become overactivated and release cytotoxic mediators such as TNFα. In an animal study published in 2025,...…
View Post 5 min This content is machine translated Adherence in severe or poorly controlled asthma Digital monitoring with potential for greater treatment adherence Despite proven pharmacological strategies for the treatment of asthma, lack of adherence to inhaled therapy remains a major problem, particularly in patients requiring a triple combination. Digital tools have shown...…
View Post 4 min This content is machine translated Crohn's disease and depression Significant psychological stress for CD patients Crohn’s disease (CD) is often associated with extraintestinal symptoms (EIM). However, the connection with mental disorders is also being increasingly emphasized. Spanish scientists analyzed the frequency and severity of depression...…
View Post 4 min This content is machine translated Epilepsy Cannabidiol for refractory epilepsy syndromes The pharmaceutical formulation of high-purity cannabidiol is approved for the treatment of seizures associated with Lennox-Gastaut syndrome, Dravet syndrome and tuberous sclerosis complex. Despite many years of clinical experience, there...…
View Post 3 min This content is machine translated Stomach cancer and Helicobacter pylori A question of income? Despite a declining incidence rate, the total number of cases and deaths from gastric cancer continues to rise worldwide. Infection with Helicobacter pylori is the main risk factor for the...…
View Post 4 min This content is machine translated Cutaneous Crohn's disease Effective alternative to TNF inhibitors Cutaneous Crohn’s disease (CCD) is a granulomatous skin disease that is not associated with the gastrointestinal tract. It rarely correlates with intestinal disease and often requires separate treatment. Although interleukin...…
View Post 4 min This content is machine translated Benralizumab in a patient with asthma and EGPA When the biologic has a counterproductive effect Eosinophilic vasculitis with polyangiitis (EGPA) is a rare inflammation of small blood vessels that is usually associated with asthma. Eye involvement occurs sporadically and central retinal artery occlusion (CRAO) is...…
View Post 3 min This content is machine translated Brain atrophy and MS Brain atrophy correlates with disability progression in MS Brain atrophy in MS patients, particularly in the thalamus, correlates strongly with long-term physical disability and cognitive deficits. A long-term analysis of the phase 3 studies RADIANCE/SUNBEAM and the open-label...…
View Post 4 min This content is machine translated Pulmonary sarcoidosis Prednisone vs. MTX: a draw after 24 weeks Pulmonary sarcoidosis remains a persistent clinical challenge in respiratory medicine. Although glucocorticoids have long been the mainstay of first-line therapy, their side effects often complicate long-term treatment. In recent years,...…
View Post 4 min This content is machine translated Friedreich's ataxia Loss of orientation in the cerebellum Spinocerebellar ataxias represent a large group of rare, progressive neurodegenerative diseases that affect the cerebellum and its connections and predominantly manifest themselves in a cerebellar syndrome. In addition to progressive...…
View Post 6 min This content is machine translated Subtyping as the key to precision medicine Molecular diversity of the PDAC Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive tumors of all. The five-year survival rate is still in the single digits. In recent years, however, there has been...…
