This content is machine translated Study report Sphingolipid profile in early-stage primary biliary cholangitis Using ultra-high performance liquid chromatography coupled with tandem mass spectrometry (UHPLC-MS/MS), a Polish research team discovered interesting new insights into the changes in sphingolipid metabolism in patients with early-stage primary...…
View Post 6 min This content is machine translated Angiosarcoma of the heart A diagnostic and therapeutic “black box” Primary angiosarcomas of the heart are among the rarest and most aggressive malignant tumors. The unspecific symptoms, rapid progression and complex differential diagnosis make early detection considerably more difficult. Despite...…
View Post 5 min This content is machine translated Ataxias Friedreich’s ataxia: when the energy metabolism attacks the nervous system Energy deficiency instead of pure oxidative stress: New data show that in Friedreich’s ataxia, disturbances in fatty acid and ketone body metabolism in particular contribute to selective neurodegeneration. The article...…
View Post 3 min This content is machine translated Risk of osteoporosis in autoimmune liver diseases Always determine bone density in PBC, PSC and AIH Studies show that primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC) and autoimmune hepatitis (AIH) are associated with a significantly increased risk of developing osteopenia or osteoporosis. For this reason,...…
View Post 12 min This content is machine translated NSCLC Bispecific antibodies for rare EGFR mutations Rare EGFR mutations such as exon 20 insertion changes have long been considered a therapeutic dead end in non-small cell lung cancer (NSCLC). Current data show that innovative mechanisms of...…
View Post 6 min This content is machine translated Type 2 diabetes - glycemic control and prevention of secondary diseases Utilizing pleiotropic cardio- and nephroprotective effects of SGLT-2-i and GLP-1-RA Type 2 diabetes is currently understood to be a multisystemic disease, with the prognosis being significantly influenced by cardiac and renal pathology. An early, multimodal therapeutic approach that goes beyond...…
View Post 6 min This content is machine translated Subsyndromal anxiety disorders: Family doctor as first point of contact Practical recommendations for diagnostics and therapy A consensus paper published in 2025 provides pragmatic advice on the diagnosis and treatment of subsyndromal anxiety disorder (SSA). If it has been established that the patient has SSA, it...…
View Post 12 min This content is machine translated Patient-centered rounds in medicine Aligning care with the patient Patient-centered, patient-centered medicine respects and integrates individual preferences, values, or needs and has grown in importance in patient care in recent years. In clinical care, it is therefore important that...… CME-Test
View Post 7 min This content is machine translated Restless legs syndrome in children Relationship between restless legs syndrome and growing pains When restless legs syndrome is actually behind “growing pains”. Which laboratory values should be specifically clarified. A review shows considerable overlap between the two disorders in childhood. Serotonin dysfunction, iron...…
View Post 7 min This content is machine translated Between hope and evidence gaps Tinnitus and phytotherapy Tinnitus is a highly prevalent symptom with a considerable impact on quality of life; randomized studies have not yet shown any clearly effective standard pharmacological therapy. Guidelines primarily recommend educational,...…
View Post 4 min This content is machine translated Case Report 17-year-old patient with acne fulminans In the present case, a complex interplay between inflammatory and infectious processes was found. The close temporal relationship between the dose increase of isotretinoin and the onset of symptoms suggests...…
