Cellular senescence

Cellular senescence is considered a key biological program that can exert both protective and potentially pathogenic effects in tissues across the lifespan. If senescent cells persist, they are associated with chronic inflammation, disturbed tissue homeostasis and diverse disease phenotypes. In recent years, a clinically highly relevant field of research has emerged from this: Senotherapies – in particular senolytics (selective elimination of senescent cells) and senomorphics (modulation of senescence-associated signaling and secretion patterns) – are widely studied in preclinical models, while human evidence to date comes mainly from early, small studies or from indirect clinical data sets.