Hyperreactive intraepidermal nerve fibers

Extensive scratching is known to trigger a cascade of mechanisms. An itch-scratch cycle not only impairs the barrier function of the epidermis, but also promotes neuroinflammation in the skin through the interaction between immune cells and peripheral sensory nerve fibers. At this year’s ADF Annual Meeting, studies with innovative methodology were presented that aim to find out more about the pathophysiology of chronic itch.