sFlt-1/PlGF in Preeclampsia Diagnostics: What the Ratio Can Do

The sFlt-1/PlGF ratio provides a very good answer to one question and only a partial answer to a second. It can rule out developing preeclampsia with a high degree of certainty for one to two weeks. It cannot reliably predict it. The negative predictive value is 99.3 percent, and the positive predictive value is 36.7 percent [1]. This asymmetry determines the test’s entire clinical utility.