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  • 4 minute read
  • This content is machine translated Psoriasis and metabolic comorbidities: new study data

GLP-1RAs showed a valuable dual benefit

GLP-1RAs, including semaglutide and liraglutide, are frequently used today for the treatment of type 2 diabetes and obesity. A recent study investigated whether and how overweight and/or diabetic psoriasis patients benefit from treatment with GLP-1RAs. Initial results were presented at this year’s congress of the European Academy of Dermatology and Venereology (EADV)…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here
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  • 5 minute read
  • This content is machine translated Heart failure: combination of four as "Guideline-Directed Medical Therapy"

Standard established at HFrEF with individual nuances

The modern treatment of heart failure is characterized by early intervention, multidimensional care and extended therapy options. Around half of all heart failure patients have a reduced left ventricular ejection fraction. With regard to drug therapy, according to ESC guidelines, there are four standard recommended drug classes that should be used early in HFrEF, as they are particularly important for reducing morbidity and mortality. SGLT-2 inhibitors are now recommended for HFrEF, HFmrEF and HFpEF…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here
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  • 7 minute read
  • This content is machine translated Chronic inflammation as a driver of ageing

Immunosenescence and inflammaging

Immunosenescence and inflammaging are now regarded as central biological mechanisms of ageing. The age-related altered immune system is both weakened and chronically activated – with consequences for susceptibility to infection, tumor development and the large group of inflammation-driven cardiometabolic diseases. In the following, central molecular mechanisms, clinical manifestations and potential intervention approaches are summarized based on current reviews and primary studies on immunosenescence, chronic inflammation and age-associated diseases…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here
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  • 8 minute read
  • This content is machine translated Evidence, limitations and practical implications

Phytotherapy for anxiety disorders

Anxiety disorders are among the most common mental illnesses – and many sufferers want “natural” treatment options in addition to or as an alternative to conventional psychotropic drugs. For some herbal active ingredients – in particular standardized lavender oil, kava (Piper methysticum), ashwagandha (Withania somnifera), passion flower (Passiflora incarnata) and chamomile (Matricaria chamomilla) – a clinical database of randomized studies, systematic reviews and meta-analyses is now available. This shows that there are demonstrable anxiolytic effects, albeit with varying effect strengths, quality levels and safety profiles. The article summarizes the current evidence and outlines the clinical situations in which phytotherapeutic options can be…
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  • 3 minute read
  • This content is machine translated Case report: Hiccups after ketoacidosis

Nebulized lidocaine brings relief

Persistent hiccups are a rare but distressing symptom that can significantly affect the quality of life of patients with diabetic ketoacidosis (DKA). In one clinical case, treatment with inhaled nebulized lidocaine was reported in a patient whose hiccups did not respond to standard drug therapy. The method led to rapid and complete relief of symptoms…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here
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  • 6 minute read
  • This content is machine translated Hidradenitis suppurativa: biologics reduce inflammatory processes

Treatment recommendations depend on the severity and inflammatory activity

Due to its phenotypic heterogeneity and multifactorial pathogenesis, hidradenitis suppurativa is a complex disease that can be difficult to treat. Fortunately, research has achieved significant breakthroughs in the recent past, which is reflected in the fact that several biologics are now available and a number of drug candidates from the field of monoclonal antibodies and small molecules are being tested in trials. The further development of the therapy spectrum and other innovations are reflected in the recently published European S2k guideline…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here
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  • 7 minute read
  • This content is machine translated Dizziness as a leading symptom: new consensus paper

Current recommendations for handling in everyday practice

Dizziness is one of the 20 most common causes of consultation in GP practices. Most causes of dizziness can already be clarified at the primary care level, but the broad differential diagnostic spectrum and limited time resources are limiting factors, as Tarnutzer et al. stated – their consensus paper was developed based on the results of a prior survey of primary care and neuro-otology physicians in Switzerland…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here
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  • 12 minute read
  • This content is machine translated Endometrial carcinoma, malignant melanoma and NSCLC in focus

Personalized mRNA and neoantigen vaccines in oncology

mRNA technology has experienced its global breakthrough as a result of the COVID-19 pandemic and has long been clinically established. In oncology, however, the actual translation is only now beginning. Opportunities and risks are closely linked – from precise immune activation to the challenge of tumor heterogeneity. Preclinical models demonstrate the potential of mRNA and neoantigen vaccines; clinical studies and congress reports show promising results in melanoma, pancreatic carcinoma, endometrial carcinoma and other tumor entities…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here
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  • 5 minute read
  • This content is machine translated Consequences for pathophysiology, clinic and therapy

The inflammatory subgroup of major depression

Major depression remains one of the leading causes of disability and suicidality worldwide. A key reason for the inadequate effectiveness of many treatments is their marked biological and clinical heterogeneity. The available evidence indicates that chronically increased inflammatory activity is a key pathophysiological mechanism in a relevant proportion of those affected. This inflammatory subgroup shows characteristic biomarker profiles, specific symptom clusters, a particular interaction with neurotransmitter systems and a differentiated response to forms of therapy. The precise characterization of this subtype can make a decisive contribution to the further development of targeted, mechanistically based personalized psychiatry…. Dieser Inhalt ist nur für Benutzer der Gruppe:…
  • This content is machine translated Clostridioides difficile infection: specific therapy

Importance of vancomycin and fidaxomicin has increased

C. difficile infection (CDI) is the most common pathogen-related cause of nosocomial diarrhea, but can also occur in outpatients if risk factors are present. Due to the associated morbidity and mortality risks, there is usually an indication for specific treatment in the case of a diagnosed CDI. The use of oral antibiotics remains the most important measure, although previous antibiotic treatment is the main risk factor for the development of CDI…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here
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  • This content is machine translated Alternative to insulin and GLP1

From the β-cell to the center: the versatile role of amylin

Although amylin was discovered decades ago, its importance in everyday clinical practice has long been underestimated. New pharmacological developments are increasingly bringing amylin into the focus of diabetes and obesity therapy, and amylin analogs, some of which have already passed phase 3 clinical trials, are now among the most promising approaches in overweight and obesity pharmacotherapy…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here
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  • This content is machine translated Rare diseases

Yellow nail and Swyer-James syndrome

Yellow nail syndrome (YNS) is a rare disease associated with yellowing of the nails, pulmonary manifestations and lymphoedema. A clinical examination and examination of the fingernails can provide valuable information on pneumological diseases. Swyer-James syndrome (SJS) is a rare form of post-infectious bronchiolitis obliterans that usually occurs after viral respiratory infections. The typical radiological manifestation is a difference in lung translucency. The affected lung appears hypertransparent. Rare diseases such as YNS and SJS can manifest as recurrent pulmonary infections and bronchiectasis…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here
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  • This content is machine translated AI in neurology

Control instead of a flood of data: AI makes big data and wearables usable

Artificial intelligence has become a key technology in medicine, including in complex neurology. Modern methods such as machine learning and deep learning in combination with data and wearables (wearable sensor technology) enable more precise diagnostics, prognoses and treatment decisions…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here
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  • This content is machine translated Diabetic ketoacidosis

Recommendations for action in practice

Diabetic ketoacidosis (DKA) is an acutely life-threatening complication of diabetes mellitus that occurs predominantly in type 1 diabetes, but is also increasingly occurring in people with type 2 diabetes. A special form is euglycemic DKA, which mainly occurs during therapy with SGLT2 inhibitors. Even though it has become rare and the mortality rate is now only just over 1%, these deaths are usually preventable. Timely diagnosis, standardized treatment protocols and, above all, prophylaxis are crucial for the prognosis…. Dieser Inhalt ist nur für Benutzer der Gruppe: Medizinische Fachperson zugänglich Jetzt beitretenAlready a member? Log in here
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