Wolfram syndrome

The term “DIDMOAD” syndrome – an acronym for the characteristic symptoms – serves as an alternative name for this autosomal recessive neurodegenerative disease, which was first described in 1938: Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy and Deafness/Deafness. In the majority of patients, mutations in the WFS1 gene can be detected.