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General Internal Medicine

1871 posts
  • This content is machine translated Obesity as a chronic disease: an interdisciplinary perspective

Neurobiological mechanisms of obesity

A high-fat and high-sugar diet affects both the homeostatic hunger and satiety signals in the hypothalamus and the hedonic reward system, leading to persistent hunger and a strong craving for...…
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  • 3 min
  • This content is machine translated Phimosis and penile cancer under SGLT2i

Increased risk for men with T2D

In recent years, sodium-glucose cotransporter 2 inhibitors (SGLT2i) have been widely used in the treatment of type 2 diabetes, as they not only provide improved glycemic control, but also offer...…
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  • 4 min
  • This content is machine translated Therapy of non-tumor-related pain

Do not prescribe opioids lightly for musculoskeletal pain

A UK research team used electronic primary care patient records from 2006-2021 based on the Clinical Research Practice Datalink (CPRD) to identify opioid prescriptions. The analyses revealed that almost three...…
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  • 9 min
  • This content is machine translated Irritable Bowel Syndrome

“Best practice” recommendations for step-by-step clarification and stage-adapted therapy

The diagnosis of irritable bowel syndrome (IBS) is based on the Rome IV criteria for functional gastrointestinal disorders. The main symptoms are abdominal pain and altered bowel habits, but patients...…
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  • 10 min
  • This content is machine translated A hub of biological aging

Mitochondrial dysfunction and energy metabolism

Mitochondrial dysfunction is not defined as an isolated “ATP problem” in the Hallmarks of Ageing framework, but as a systemic shift in bioenergetics, redox signaling, quality control and immune metabolism....…
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  • 4 min
  • This content is machine translated Study report

Sphingolipid profile in early-stage primary biliary cholangitis

Using ultra-high performance liquid chromatography coupled with tandem mass spectrometry (UHPLC-MS/MS), a Polish research team discovered interesting new insights into the changes in sphingolipid metabolism in patients with early-stage primary...…
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  • 3 min
  • This content is machine translated Health Literacy

Promoting health literacy: from the abstract to the concrete level

The Federal Council’s health policy strategy “Health 2030” sets out a framework for action in health policy aimed at securing healthcare provision in the coming years. The second of the...…
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  • 4 min
  • This content is machine translated Case study

Wiedemann-Steiner syndrome in a 2-year-old girl

The patient, who had a phenotype characterized by hypertelorism, thick eyebrows and other features, was found to have a c.517C>T nonsense mutation in the KMT2A gene. This rare heterozygous mutation...…
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  • 4 min
  • This content is machine translated Chronic back pain

Care in the virtual hospital – the Back@home project

As part of the Back@Home study, the effectiveness of a virtual hospital model is being evaluated in patients with musculoskeletal back pain who present to the emergency room. One of...…
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  • 5 min
  • This content is machine translated Study report: TBS v3 and v4 in comparison

Analysis of OsteoLaus study data

The OsteoLaus study is part of the prospective, population-based CoLaus/PsyColaus study of postmenopausal women in Switzerland. In an analysis published in Osteoporosis International in 2025, the Trabecular Bone Score (TBS)...…
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  • 8 min
  • This content is machine translated Psychooncology

Communication as the key to therapy adherence

Patient satisfaction and adherence depend crucially on the doctor-patient discussion. Communication skills are usually the key to success here. Good interview conditions, sufficient time and an empathetic approach to the...…
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