This content is machine translated TRK Inhibitors Entity-independent cancer therapy: a glimpse of the future? Since 2020, two TRK inhibitors have been approved in Switzerland for tumor diagnosis, i.e. independent of tumor entity. They are designed to treat any solid tumor with NTRK gene fusions,…
View Post 2 min This content is machine translated Spinal muscular atrophy Single-agent gene therapy shows transformative therapeutic benefit New trial data demonstrate age-appropriate development and achievement of motor milestones in presymptomatic children with SMA using single-agent gene therapy, without any respiratory or nutritional support or serious treatment-related adverse…
View Post 11 min This content is machine translated Atopic dermatitis The role of the key cytokine IL-13 The Th2 response of atopic dermatitis is strongly controlled by IL-13, which activates the type II receptor by binding to the IL-13Rα chain. IL-13 is expressed at higher levels than… CME-Test
View Post 7 min This content is machine translated Aesthetic medicine Too much/too little hair – non-drug treatments Originally, humans were hairy all over their bodies until a few 100,000 years ago, when a pseudogene essential for keratin formation slowly lost its functionality for hair follicles in certain… CME-Test
View Post 2 min This content is machine translated Leukemic cutaneous T-cell lymphoma (L-CTCL) Sézary syndrome and mycosis fungoides: STAT5 as a therapeutic target? As the disease progresses, the tumor cells in leukemic variants of cutaneous T-cell lymphomas spread not only in the skin but also in the blood and lymph nodes. Although an…
View Post 4 min This content is machine translated Granulomatous diseases - an update News and interesting facts about pathomechanisms and treatment Both infectious and noninfectious granulomatous dermatoses are very heterogeneous clinical pictures. Treatment is based on pathogenesis and is primarily anti-inflammatory, with corticosteroids still playing an important role. A new therapeutic…
View Post 6 min This content is machine translated Liquid Biopsy The future of oncological diagnostics With the increasing variety of personalized and immuno-oncological therapeutic options, the importance of predictive markers is also increasing. To date, tissue diagnostics, including invasive biopsy, are necessary to determine this.…
View Post 5 min This content is machine translated News from the lung cancer pipeline First targeted substance in KRAS mutation and bispecific immunotherapy While targeted therapies in non-small cell lung cancer (NSCLC) have been on the rise for years, such an option for KRAS-mutatedtumors has been lacking. The small molecule inhibitor Sotorasib, which…
View Post 7 min This content is machine translated Non-infectious complications after HSCT Cure for multiple sclerosis at any price? Hematopoietic stem cell transplantation (HSCT) is used as ultima ratio in multiple sclerosis. The reboot of the immune system is aimed at healing, but carries strong side effects. Both infectious…
View Post 5 min This content is machine translated Relapsed/refractory multiple myeloma The BCMA molecule as a beacon of hope The prognosis in relapsed and refractory multiple myeloma (RRMM) remains grim. Now, at the annual meeting of the American Society of Hematology (ASH), data have been presented that raise faint…
View Post 4 min This content is machine translated Chronic inflammatory bowel disease (CED) Two new biomarkers identified for targeted therapy Surrogate markers have an important role in the disease management of IBD. Researchers found evidence that microbial butyrate synthesis may predict therapeutic efficacy and thus play an important role in…
