This content is machine translated Psoriasis Research: What's in the Pipeline? Highly selective oral TYK inhibitors in Phase III Envudeucitinib and Zasocitinib are oral, allosteric tyrosine kinase 2 (TYK2) inhibitors currently being evaluated in clinical trials for plaque psoriasis. The interim results presented during the Late-Breaking Research sessions at...…
View Post 6 min This content is machine translated Treatment resistant depression Esketamine nasal spray as monotherapy? New for treatment-resistant depression Despite a variety of approved antidepressant treatments, major depressive disorder (MDD) remains one of the leading causes of disability worldwide and has been shown to shorten the life expectancy of...…
View Post 3 min This content is machine translated Dementia risk with type 2 diabetes SGLT2 inhibitors with advantages vs. DPP4 inhibitors SGLT2 inhibitors are associated with a significantly lower risk of dementia, including Alzheimer’s disease and vascular dementia, compared to DPP4 inhibitors. The observed benefit was consistent across different subgroups and...…
View Post 4 min This content is machine translated Cannabis for schizophrenia CBD pre-treatment could exacerbate side effects A significant proportion of people with schizophrenia use cannabis, with around one in five meeting the criteria for a comorbid cannabis use disorder, for which there are still limited effective...…
View Post 4 min This content is machine translated Risk of psychosis Modulate cortical excitatory activity with diazepam Individuals at clinical high risk for psych osis (CHRp) have an estimated 27% chance of developing a psychotic disorder within three years, but there are currently no established preventive pharmacological...…
View Post 6 min This content is machine translated MASLD/MASH: lifestyle, pharmacotherapy, bariatric procedures Addressing metabolic drivers and counteracting fibrosis Steatotic liver diseases that are not associated with alcohol consumption are now referred to as metabolic steatotic liver disease (MASLD) or metabolic dysfunction-associated steatohepatitis (MASH). There is now no need...…
View Post 6 min This content is machine translated Chronic urticaria: new treatment alternatives in sight If antihistamines are not sufficient and IgE levels are low Chronic urticaria often leads to a high level of suffering, but new treatment options are on the way – a lot has happened since the publication of the current S3...…
View Post 15 min This content is machine translated Cardiovascular health in women Hormonal contraception, stress disorders and cardiovascular risk in women Cardiovascular disease is the leading cause of death in women, and stress-related psychiatric disorders are considered cardiovascular risk factors in their own right. Hormonal contraceptives, which are used by around...…
View Post 8 min This content is machine translated Obesity treatment: new study data Incretin mimetics for comorbidities such as type 2 diabetes, ASCVD, HF, OSAS Lifestyle-related measures are the basic framework in the treatment of overweight and obesity. However, in order to achieve and maintain the target weight, accompanying pharmacological or surgical measures are usually...…
View Post 12 min This content is machine translated Anticoagulation after cerebral hemorrhage with atrial fibrillation What PRESTIGE-AF answers – and what remains unanswered According to study results, direct oral anticoagulation (DOAC) can effectively prevent ischemic strokes in survivors of intracerebral hemorrhage with atrial fibrillation. However, the results also show a relevant increase in...…
View Post 15 min This content is machine translated MASH and heart health The underestimated cardiovascular threat Metabolic-associated steatohepatitis (MASH) was long considered a purely hepatic problem. Today, data from large clinical trials and registries clearly show that cardiovascular disease is the most common cause of death...…
