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Pharmacology and toxicology

373 posts
  • This content is machine translated Tinea capitis: Current Guidelines and Recommendations

What should be kept in mind when treating adult patients?

Tinea capitis is less common in adults, but its incidence is on the rise. From a diagnostic perspective, one should be on the lookout for pathogens that are rather atypical...…
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  • 5 min
  • This content is machine translated Viloxazine for ADHD

A non-stimulating option—but with limited evidence

ADHD affects about 5–7% of children and adolescents and 2–5% of adults. Although it is generally considered a childhood disorder, symptoms persist into adulthood for the majority of those affected....…
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  • 6 min
  • This content is machine translated Schizophrenia in the early-onset stage

Which antipsychotic should be used for treatment-naive patients?

Schizophrenia often develops during adolescence or early adulthood. Neurocognitive deficits frequently occur before or during the first psychotic episode and are closely associated with poorer functional outcomes. However, the effects...…
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  • 6 min
  • This content is machine translated Psoriasis: therapy with biologics and TYK-2-i

Progress assessments based on current long-term and real-world data

A broad spectrum of systemic agents is now available for the treatment of moderate to severe psoriasis. At this year’s DDG congress “Dermatology compact + practical”, various studies were presented...…
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  • 4 min
  • This content is machine translated Escitalopram for anxiety disorders

Positive effect, but no immediate improvement in symptoms

Anxiety disorders are among the most common psychiatric illnesses worldwide. There is evidence that both the amygdala and the dorsomedial cortex are involved in the pathophysiology. Selective serotonin reuptake inhibitors...…
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  • 4 min
  • This content is machine translated Ozanimod for relapsing-remitting multiple sclerosis

Signs of improved tolerability with prolonged treatment

Ozanimod, a selective modulator of sphingosine-1-phosphate (S1P) receptors 1 and 5, has demonstrated efficacy in relapsing-remitting multiple sclerosis (RMS) in Phase 2 and 3 studies. At a dose of 0.92...…
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  • 6 min
  • This content is machine translated Treatment resistant depression

Esketamine nasal spray as monotherapy? New for treatment-resistant depression

Despite a variety of approved antidepressant treatments, major depressive disorder (MDD) remains one of the leading causes of disability worldwide and has been shown to shorten the life expectancy of...…
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  • 3 min
  • This content is machine translated Dementia risk with type 2 diabetes

SGLT2 inhibitors with advantages vs. DPP4 inhibitors

SGLT2 inhibitors are associated with a significantly lower risk of dementia, including Alzheimer’s disease and vascular dementia, compared to DPP4 inhibitors. The observed benefit was consistent across different subgroups and...…
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  • 4 min
  • This content is machine translated Cannabis for schizophrenia

CBD pre-treatment could exacerbate side effects

A significant proportion of people with schizophrenia use cannabis, with around one in five meeting the criteria for a comorbid cannabis use disorder, for which there are still limited effective...…
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  • 4 min
  • This content is machine translated Risk of psychosis

Modulate cortical excitatory activity with diazepam

Individuals at clinical high risk for psych osis (CHRp) have an estimated 27% chance of developing a psychotic disorder within three years, but there are currently no established preventive pharmacological...…
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  • 6 min
  • This content is machine translated MASLD/MASH: lifestyle, pharmacotherapy, bariatric procedures

Addressing metabolic drivers and counteracting fibrosis

Steatotic liver diseases that are not associated with alcohol consumption are now referred to as metabolic steatotic liver disease (MASLD) or metabolic dysfunction-associated steatohepatitis (MASH). There is now no need...…

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