This content is machine translated Update 2025 Hypercholesterolemia The past 18 months have noticeably shifted the LDL-lowering landscape: An ESC/EAS-Focused Update 2025 sharpens the indication thresholds, real-world data confirm the benefit of early combinations after myocardial infarction, bempedoic...…
View Post 8 min This content is machine translated GPP: from molecular principles to targeted therapy Therapeutic rationale for targeted IL-36 receptor inhibition The progress in the diagnosis and treatment of generalized pustular psoriasis (GPP) is remarkable. GPP has developed into a clearly defined, independent, IL-36-mediated autoinflammatory disease. Today, the high chronic disease...…
View Post 8 min This content is machine translated HFpEF 2025 Precision medicine and phenotypes In 2025, heart failure with preserved ejection fraction (HFpEF) is less than ever a single clinical picture – it is an umbrella over many phenotypes with different triggers, pathomechanisms and...…
View Post 9 min This content is machine translated Myelofibrosis New treatment options for myelofibrosis patients with a high risk of anemia? Myelofibrosis is considered one of the most complex myeloproliferative neoplasms – with high symptom burden, progressive cytopenia and limited treatment options – with anemia in particular presenting a clinical challenge...…
View Post 6 min This content is machine translated Chronic insomnia in adults: Guideline recommendations CBT-i as first choice – pharmacotherapy as secondary intervention Sleep disorders are often associated with pronounced daytime sleepiness, difficulty concentrating and increased feelings of stress. Diagnosis is generally based on the clinical history; if necessary, an actigraphy or polysomnigraphy...…
View Post 15 min This content is machine translated Pulmonary hypertension PH and lung diseases Pulmonary hypertension (PH) describes a hemodynamic condition with a pathological increase in pressure in the pulmonary vascular circulation. Clinically, PH causes reduced performance, shortness of breath, angina and syncope. Comprehensive...… CME-Test
View Post 16 min This content is machine translated IBDmatters - Synergy effects for IBD pathways How combination therapies lead to better treatment results Inflammatory bowel diseases (IBD) are complex and multifactorial diseases that require a differentiated and evolving treatment approach. When monotherapies reach their limits, the need for combination strategies grows. The focus...… CME-Test
View Post 4 min This content is machine translated Chronic hand eczema Topical pan-JAK-i vs. systemic retinoid: head-to-head study Alitretinoin is currently the only systemic treatment approved for severe chronic hand eczema when patients do not respond adequately to topical corticosteroids. The topical pan-Janus kinase (JAK) inhibitor delgocitinib is...…
View Post 6 min This content is machine translated Study report Long-term data on CFTR modulators in children with cystic fibrosis Cystic fibrosis (CF) is one of the most common congenital metabolic diseases in Europe. The treatment options for CF patients have expanded significantly in recent years. CFTR modulators improve the...…
View Post 5 min This content is machine translated Multiple sclerosis Multiple sclerosis 2025: New strategies against progression and the role of microglia The treatment of multiple sclerosis has made enormous progress thanks to highly effective disease-modifying therapies, in particular anti-CD20 antibodies. For most newly diagnosed patients, a life without disability is realistic....…
View Post 8 min This content is machine translated A syndrome between decompensation and chronification Worsening Heart Failure The deterioration of chronic heart failure – so-called worsening heart failure (WHF) – is no longer solely an acute event, but an expression of complex, often repetitive pathophysiological dynamics. Despite...…
