Extent of weight reduction is prognostically relevant

According to the World Health Organization (WHO), obesity is one of the greatest health risks. With increasing severity, the risk of various concomitant and secondary diseases increases
. Obesity-related multimorbidity is complex, and weight reduction can have a health-promoting effect at various levels. Today, five therapeutic pillars are available for the treatment of obesity, including drug interventions using incretin analogs such as semaglutide and tirzepatide.