Parkinson’s disease (PD) is a neurodegenerative disease characterized by a progressive loss of dopaminergic neurons in the substantia nigra pars compacta. Oxidative stress is increasingly being discussed as a key process in the development and progression of the disease. This is triggered and maintained by multiple factors, including mitochondrial dysfunction, defective dopamine metabolism and chronic neuroinflammation. The resulting imbalance between reactive oxygen species (ROS) and antioxidant defense systems leads to pronounced cellular damage, which ultimately drives the degeneration of dopaminergic cells. Despite intensive research, no curative therapy exists to date.
You May Also Like
- Practice Management
Improved quality of care aims for satisfied patients
- Chemsex - MSM, sex, chrystal meth & co.
Medical and psychosocial perspectives
- Bladder cancer
Tuberculosis vaccination reduces recurrences
- Oral JAK-i in atopic dermatitis
Benefits and risks: What does the current data say?
- Sleep-wake disorders in pneumology practice
Patience, knowledge and persistence in therapy
- Chronic lung diseases
Sarcopenia and malnutrition in the context of pneumological rehabilitation
- Cardiovascular risk and obesity
Pathomechanisms, secondary prevention and treatment options
- Oxidative stress and neurodegeneration