Insights and therapeutic strategies for Parkinson’s disease

Parkinson’s disease (PD) is a neurodegenerative disease characterized by a progressive loss of dopaminergic neurons in the substantia nigra pars compacta. Oxidative stress is increasingly being discussed as a key process in the development and progression of the disease. This is triggered and maintained by multiple factors, including mitochondrial dysfunction, defective dopamine metabolism and chronic neuroinflammation. The resulting imbalance between reactive oxygen species (ROS) and antioxidant defense systems leads to pronounced cellular damage, which ultimately drives the degeneration of dopaminergic cells. Despite intensive research, no curative therapy exists to date.