St. John’s wort and SSRIs

The efficacy of St. John’s wort preparations for the treatment of mild and moderate major depression has been compared on several occasions with selective serotonin reuptake inhibitors (SSRIs). St. John’s wort (Hypericum perforatum) proved to be equal or even superior. Recently, the most comprehensive meta-analysis to date comparing Hypericum preparations with the most common SSRIs has been published.