Why is it so hard to lose weight?

Obesity is the most common chronic disease in Western societies, with serious metabolic, cardiovascular, and psychosocial consequences. The therapeutic landscape has changed fundamentally: new-generation GLP-1 agonists achieve weight loss that, just a few years ago, was reserved solely for bariatric surgery. This presents physicians with a clear task: to understand obesity as a biologically based chronic disease and to treat it accordingly.