This content is machine translated Digital biomarkers Continuous monitoring using digital biomarkers in MS care Digital biomarkers could fundamentally change MS care: A study shows that wearables and smartphone tests reliably map disability (EDSS) and fatigue (FSMC) in everyday life. Motor performance data and heart...…
View Post 8 min This content is machine translated Benefits, limits and safety aspects Phytotherapy for cardiovascular diseases Herbal preparations and “natural” dietary supplements are frequently used by patients with cardiovascular disease – often in the hope of “gently” influencing blood pressure, lipids or symptoms. However, guidelines from...…
View Post 6 min This content is machine translated Results of the FOREST HCM study Symptomatic obstructive hypertrophic cardiomyopathy Myosin inhibition is considered a key therapeutic approach in the treatment of obstructive hypertrophic cardiomyopathy (oHCM). In addition to mavacamten, aficamten is now being clinically investigated as a potentially short-acting,...…
View Post 9 min This content is machine translated Neuroprotection, resilience and cognitive health in old age Longevity & Brain Cognitive health in old age is not an inevitable fate, but can be influenced to a relevant extent by modifiable factors. The Lancet Commission 2024 concludes that a significant proportion...…
View Post 6 min This content is machine translated Obesity as a chronic disease: an interdisciplinary perspective Neurobiological mechanisms of obesity A high-fat and high-sugar diet affects both the homeostatic hunger and satiety signals in the hypothalamus and the hedonic reward system, leading to persistent hunger and a strong craving for...…
View Post 5 min This content is machine translated Oncolytic virus in stage II melanoma Innovative method for predicting therapy response Until now, it was assumed that TVEC works by activating T cells. However, in a study by British and US scientists published in JCO Oncology Advances, the T cell populations...…
View Post 3 min This content is machine translated Phimosis and penile cancer under SGLT2i Increased risk for men with T2D In recent years, sodium-glucose cotransporter 2 inhibitors (SGLT2i) have been widely used in the treatment of type 2 diabetes, as they not only provide improved glycemic control, but also offer...…
View Post 6 min This content is machine translated Migraine: better quality of life thanks to multimodal care Broader selection of innovative migraine prophylactics and acute therapies The fact that migraine therapy is changing is also reflected in the recent publication of the updated S1 guideline “Treatment of migraine attacks and prophylaxis of migraine”. Although triptans are...…
View Post 4 min This content is machine translated Therapy of non-tumor-related pain Do not prescribe opioids lightly for musculoskeletal pain A UK research team used electronic primary care patient records from 2006-2021 based on the Clinical Research Practice Datalink (CPRD) to identify opioid prescriptions. The analyses revealed that almost three...…
View Post 3 min This content is machine translated Migraine Fremanezumab for comorbid migraine and depression Migraine and depression often reinforce each other and make treatment more difficult. The UNITE study shows that the CGRP antibody fremanezumab significantly reduces both migraine days and depressive symptoms –...…
View Post 10 min This content is machine translated A hub of biological aging Mitochondrial dysfunction and energy metabolism Mitochondrial dysfunction is not defined as an isolated “ATP problem” in the Hallmarks of Ageing framework, but as a systemic shift in bioenergetics, redox signaling, quality control and immune metabolism....…
