Hyperkeratosis lenticularis perstans aka Flegel’s disease

Flegel’s disease is a genodermatosis with manifestation in the second half of life. Topical topical preparations such as those containing urea or cortisone are currently used for therapy. To clarify the genetic cause of this rare dyskeratosis, a research team from Germany and Switzerland conducted a study using next-generation sequencing. The results of the analysis provide valuable insights for the development of new therapeutic approaches.