This content is machine translated Friedreich's ataxia Interim analyses of the PROFA study show “Unmet needs” The PROFA study focuses, among other things, on patient-reported psychosocial effects of Friedreich’s ataxia (FRDA) at different stages of the disease. The study comprises a cohort of FRDA patients in...…
View Post 5 min This content is machine translated Ataxias Friedreich’s ataxia: when the energy metabolism attacks the nervous system Energy deficiency instead of pure oxidative stress: New data show that in Friedreich’s ataxia, disturbances in fatty acid and ketone body metabolism in particular contribute to selective neurodegeneration. The article...…
View Post 11 min This content is machine translated From statins to metformin Preventive pharmacology and longevity In medicine, “longevity” is now less anti-ageing marketing than a very specific question of precision prevention: which pharmacological interventions prevent (or delay) cardiometabolic, renal, oncological and functional endpoints – and...…
View Post 6 min This content is machine translated What biomarkers reveal about "biological youth" - and what not (yet) Epigenetic ageing In recent years, epigenetic clocks based on DNA methylation have evolved from research tools to widely used biomarkers of biological ageing. They correlate not only with chronological age, but also...…
View Post 7 min This content is machine translated Chronic inflammation as a driver of ageing Immunosenescence and inflammaging Immunosenescence and inflammaging are now regarded as central biological mechanisms of ageing. The age-related altered immune system is both weakened and chronically activated – with consequences for susceptibility to infection,...…
View Post 12 min This content is machine translated Endometrial carcinoma, malignant melanoma and NSCLC in focus Personalized mRNA and neoantigen vaccines in oncology mRNA technology has experienced its global breakthrough as a result of the COVID-19 pandemic and has long been clinically established. In oncology, however, the actual translation is only now beginning....…
View Post 7 min This content is machine translated Focus on new therapeutic targets and senolytics Cellular senescence Cellular senescence is considered a key biological program that can exert both protective and potentially pathogenic effects in tissues across the lifespan. If senescent cells persist, they are associated with...…
View Post 10 min This content is machine translated A hub of biological aging Mitochondrial dysfunction and energy metabolism Mitochondrial dysfunction is not defined as an isolated “ATP problem” in the Hallmarks of Ageing framework, but as a systemic shift in bioenergetics, redox signaling, quality control and immune metabolism....…
View Post 4 min This content is machine translated Case study Wiedemann-Steiner syndrome in a 2-year-old girl The patient, who had a phenotype characterized by hypertelorism, thick eyebrows and other features, was found to have a c.517C>T nonsense mutation in the KMT2A gene. This rare heterozygous mutation...…
View Post 6 min This content is machine translated New ways of neuroregeneration CRISPR and artificial intelligence The combination of precise genome editing using CRISPR and AI-supported modeling of complex CNS damage marks a paradigm shift in neuroregeneration. Adaptive, closed therapy loops are designed to address multiple...…
View Post 6 min This content is machine translated Subtyping as the key to precision medicine Molecular diversity of the PDAC Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive tumors of all. The five-year survival rate is still in the single digits. In recent years, however, there has been...…
