Diagnosis at an early stage, prognostic classifications and outlook

Cardiac amyloidosis, especially wild-type transthyretin amyloid cardiomyopathy (ATTRwt-CA), has become increasingly important in recent years. Originally, it was considered a rare disease with a (mostly) late age of manifestation. Recent findings and improved imaging (in particular using bone-specific tracers in scintigrams and speckle-tracking echocardiography) have shown that ATTRwt-CA is more common than suspected in older patients with restrictive/hypertrophic findings.