Pharmacotherapy in HFrEF and HFmrEF – Combination of four as gold standard.

Important therapeutic goals in chronic heart failure are to improve quality of life and to reduce the risk of hospitalization and mortality. According to current evidence, guideline-based therapy with the four drug groups ACE inhibitors/ARNIs, beta blockers, mineralocorticoid receptor antagonists and SGLT-2 inhibitors achieves the best effects. This has been proven in various studies.