This content is machine translated A hub of biological aging Mitochondrial dysfunction and energy metabolism Mitochondrial dysfunction is not defined as an isolated “ATP problem” in the Hallmarks of Ageing framework, but as a systemic shift in bioenergetics, redox signaling, quality control and immune metabolism....…
View Post 4 min This content is machine translated Case study Wiedemann-Steiner syndrome in a 2-year-old girl The patient, who had a phenotype characterized by hypertelorism, thick eyebrows and other features, was found to have a c.517C>T nonsense mutation in the KMT2A gene. This rare heterozygous mutation...…
View Post 6 min This content is machine translated What biomarkers reveal about "biological youth" - and what not (yet) Epigenetic ageing In recent years, epigenetic clocks based on DNA methylation have evolved from research tools to widely used biomarkers of biological ageing. They correlate not only with chronological age, but also...…
View Post 6 min This content is machine translated New ways of neuroregeneration CRISPR and artificial intelligence The combination of precise genome editing using CRISPR and AI-supported modeling of complex CNS damage marks a paradigm shift in neuroregeneration. Adaptive, closed therapy loops are designed to address multiple...…
View Post 7 min This content is machine translated Focus on new therapeutic targets and senolytics Cellular senescence Cellular senescence is considered a key biological program that can exert both protective and potentially pathogenic effects in tissues across the lifespan. If senescent cells persist, they are associated with...…
View Post 7 min This content is machine translated Chronic inflammation as a driver of ageing Immunosenescence and inflammaging Immunosenescence and inflammaging are now regarded as central biological mechanisms of ageing. The age-related altered immune system is both weakened and chronically activated – with consequences for susceptibility to infection,...…
View Post 11 min This content is machine translated From statins to metformin Preventive pharmacology and longevity In medicine, “longevity” is now less anti-ageing marketing than a very specific question of precision prevention: which pharmacological interventions prevent (or delay) cardiometabolic, renal, oncological and functional endpoints – and...…
View Post 6 min This content is machine translated Subtyping as the key to precision medicine Molecular diversity of the PDAC Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive tumors of all. The five-year survival rate is still in the single digits. In recent years, however, there has been...…
View Post 12 min This content is machine translated HER2-positive breast cancer ENPP1 as a biomarker for poor prognosis and early detection of brain metastases Around 15-20% of all breast cancer cases are HER2-positive, which is a subtype with an aggressive course and an increased tendency to metastasize to the brain. A new study now...…
View Post 16 min This content is machine translated IBDmatters - Synergy effects for IBD pathways How combination therapies lead to better treatment results Inflammatory bowel diseases (IBD) are complex and multifactorial diseases that require a differentiated and evolving treatment approach. When monotherapies reach their limits, the need for combination strategies grows. The focus...… CME-Test
View Post 6 min This content is machine translated Pediatric multiple sclerosis Early high efficacy as the key to improving prognosis Pediatric multiple sclerosis (POMS) is a rare but particularly challenging form of the disease. Children and adolescents with MS often experience more relapses, a greater lesion burden on MRI and...…
