This content is machine translated Subtyping as the key to precision medicine Molecular diversity of the PDAC Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive tumors of all. The five-year survival rate is still in the single digits. In recent years, however, there has been...…
View Post 12 min This content is machine translated HER2-positive breast cancer ENPP1 as a biomarker for poor prognosis and early detection of brain metastases Around 15-20% of all breast cancer cases are HER2-positive, which is a subtype with an aggressive course and an increased tendency to metastasize to the brain. A new study now...…
View Post 16 min This content is machine translated IBDmatters - Synergy effects for IBD pathways How combination therapies lead to better treatment results Inflammatory bowel diseases (IBD) are complex and multifactorial diseases that require a differentiated and evolving treatment approach. When monotherapies reach their limits, the need for combination strategies grows. The focus...… CME-Test
View Post 4 min This content is machine translated Case study Wiedemann-Steiner syndrome in a 2-year-old girl The patient, who had a phenotype characterized by hypertelorism, thick eyebrows and other features, was found to have a c.517C>T nonsense mutation in the KMT2A gene. This rare heterozygous mutation...…
View Post 6 min This content is machine translated Pediatric multiple sclerosis Early high efficacy as the key to improving prognosis Pediatric multiple sclerosis (POMS) is a rare but particularly challenging form of the disease. Children and adolescents with MS often experience more relapses, a greater lesion burden on MRI and...…
View Post 7 min This content is machine translated Management of patients after alloHCST ERS/EBMT guideline recommendations on pulmonary cGvHD After an allogeneic stem cell transplant (alloHCST), life-threatening chronic graft-versus-host disease (cGvHD) occurs again and again. This is when the donor’s immune cells attack the recipient’s body. Lung involvement in...…
View Post 8 min This content is machine translated Progressive multiple sclerosis New horizons: from BTK inhibitors to remyelination The progressive forms of multiple sclerosis – primary progressive MS (PPMS) and secondary progressive MS (SPMS) – have presented neurologists with particular challenges for decades. Unlike relapsing-remitting MS (RRMS), where...…
View Post 4 min This content is machine translated Case series Bleeding prophylaxis for von Willebrand disease Von Willebrand’s disease is predominantly inherited in an autosomal dominant manner and is the most common hereditary cause of a bleeding tendency. It is caused by a quantitative and/or qualitative...…
View Post 6 min This content is machine translated Past, present and future Biomarkers in schizophrenia Schizophrenia is one of the most complex and serious psychiatric disorders. Despite decades of research, many of its causes remain unexplained. In recent years, interest in biomarkers has grown considerably,...…
View Post 7 min This content is machine translated From genome profiles to targeted therapies Advances in breast cancer therapy in the age of molecular diagnostics The treatment of breast cancer has undergone a profound transformation over the last two decades. While clinical-pathological parameters long formed the sole basis for therapy decisions, molecular diagnostics and personalized...…
View Post 5 min This content is machine translated Findings from the TRACK-FA study Neuroimaging biomarkers in Friedreich’s ataxia Friedreich’s ataxia (FA) is a rare, autosomal recessive neurodegenerative disease whose natural history and clinical characterization have made significant progress in recent decades. Nevertheless, there is still a lack of...…
