Effects of midazolam and dexmedetomidine

With demographic change and the rising average age of cardiology patients, post-operative cognitive dysfunction (POCD) following heart surgery is becoming increasingly important in clinical terms. If it occurs, patients often suffer from memory loss, concentration problems and slower information processing for months – symptoms that can significantly impair the rehabilitation outcome and quality of life. In their comprehensive review, Tabari et al [1] summarize the current state of research on two key sedatives: Midazolam, a long-established benzodiazepine, and dexmedetomidine (DEX), a newer, highly selective α2-adrenergic agent that shows promising neuroprotective properties.