Innovative method for predicting therapy response

Until now, it was assumed that TVEC works by activating T cells. However, in a study by British and US scientists published in JCO Oncology Advances, the T cell populations showed no correlation with the success of the therapy. Instead, they found that changes in macrophages correlated with treatment response. Their pilot study used a FRET assay (iFRET), a novel tool for identifying biomarkers.