Not all precapillary PH is the same

Pulmonary arterial hypertension (PAH) is hemodynamically defined by elevated pressure in the pulmonary vascular circulation. It was long considered a “model disease” because it often affected young women with no relevant preexisting conditions. However, many patients today are older at the time of diagnosis, have concomitant cardiovascular diseases, or exhibit a cardiopulmonary phenotype characterized by impaired diffusion capacity and a history of smoking.